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Science 13 June 2003:
Vol. 300. no. 5626, pp. 1701 - 1703
DOI: 10.1126/science.1085371
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Evolution of the Protein Repertoire

Cyrus Chothia,1 Julian Gough,2 Christine Vogel,1 Sarah A. Teichmann1

Most proteins have been formed by gene duplication, recombination, and divergence. Proteins of known structure can be matched to about 50% of genome sequences, and these data provide a quantitative description and can suggest hypotheses about the origins of these processes.

1 Structural Studies Division, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.
2 Department of Structural Biology, School of Medicine, Stanford University, Stanford, CA 94305–5126, USA.

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