Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Cyrus Chothia,1Julian Gough,2Christine Vogel,1Sarah A. Teichmann1
Most proteins have been formed by gene duplication, recombination,and divergence. Proteins of known structure can be matched toabout 50% of genome sequences, and these data provide a quantitativedescription and can suggest hypotheses about the origins ofthese processes.
1 Structural Studies Division, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. 2 Department of Structural Biology, School of Medicine, Stanford University, Stanford, CA 943055126, USA.
The editors suggest the following Related Resources on Science sites:
In Science Magazine
INTRODUCTION TO SPECIAL ISSUE
Andrew M. Sugden, Barbara R. Jasny, Elizabeth Culotta, and Elizabeth Pennisi (13 June 2003) Science300 (5626), 1691.
[DOI: 10.1126/science.300.5626.1691] |Summary »|PDF »
NEWS
Elizabeth Pennisi (13 June 2003) Science300 (5626), 1694.
[DOI: 10.1126/science.300.5626.1694] |Summary »|Full Text »|PDF »
NEWS
Elizabeth Pennisi (13 June 2003) Science300 (5626), 1696.
[DOI: 10.1126/science.300.5626.1696] |Summary »|Full Text »|PDF »
S. L. Baldauf (13 June 2003) Science300 (5626), 1703.
[DOI: 10.1126/science.1085544] |Abstract »|Full Text »|PDF »
VIEWPOINT
Jonathan A. Eisen and Claire M. Fraser (13 June 2003) Science300 (5626), 1706.
[DOI: 10.1126/science.1086292] |Abstract »|Full Text »|PDF »
VIEWPOINT
Georgina M. Mace, John L. Gittleman, and Andy Purvis (13 June 2003) Science300 (5626), 1707.
[DOI: 10.1126/science.1085510] |Abstract »|Full Text »|PDF »
NEWS
Elizabeth Pennisi (10 June 2003) Science300 (5626), 1692.
[DOI: 10.1126/science.300.5626.1692] |Summary »|Full Text »|PDF »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
From the Cover: Estimating the size of the human interactome.
M. P. H. Stumpf, T. Thorne, E. de Silva, R. Stewart, H. J. An, M. Lappe, and C. Wiuf (2008)
PNAS
105, 6959-6964
|Abstract »|Full Text »|PDF »
DAhunter: a web-based server that identifies homologous proteins by comparing domain architecture.
A Three-dimensional Model of the Neprilysin 2 Active Site Based on the X-ray Structure of Neprilysin: IDENTIFICATION OF RESIDUES INVOLVED IN SUBSTRATE HYDROLYSIS AND INHIBITOR BINDING OF NEPRILYSIN 2.
S. Voisin, D. Rognan, C. Gros, and T. Ouimet (2004)
J. Biol. Chem.
279, 46172-46181
|Abstract »|Full Text »|PDF »
Simulating evolution by gene duplication of protein features that require multiple amino acid residues.