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Cyrus Chothia,1Julian Gough,2Christine Vogel,1Sarah A. Teichmann1
Most proteins have been formed by gene duplication, recombination,and divergence. Proteins of known structure can be matched toabout 50% of genome sequences, and these data provide a quantitativedescription and can suggest hypotheses about the origins ofthese processes.
1 Structural Studies Division, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. 2 Department of Structural Biology, School of Medicine, Stanford University, Stanford, CA 943055126, USA.
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