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Science 6 June 2003:
Vol. 300. no. 5625, pp. 1517 - 1518
DOI: 10.1126/science.1086053
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Perspectives

MOLECULAR BIOLOGY:
A Self-Help Guide for a Trim Genome

Eric U. Selker

Organisms have developed a range of mechanisms to protect their genomes from being usurped by selfish DNAs such as transposons. In a Perspective, Selker describes an efficient genome defense system in the ciliated protozoan Tetrahymena that prevents unnecessary DNA sequences from being amplified in the workhorse nucleus (macronucleus) of this organism (Yao et al.).

The author is in the Department of Biology and Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA. E-mail: selker{at}molbio.uoregon.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
RNA Interference and mRNA Silencing, 2004: How Far Will They Reach?.
T. Pederson (2004)
Mol. Biol. Cell 15, 407-410
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