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Originally published in Science Express on 1 May 2003
Science 30 May 2003:
Vol. 300. no. 5624, pp. 1399 - 1404
DOI: 10.1126/science.1085953

Research Articles

The Genome Sequence of the SARS-Associated Coronavirus

Marco A. Marra,1* Steven J. M. Jones,1 Caroline R. Astell,1 Robert A. Holt,1 Angela Brooks-Wilson,1 Yaron S. N. Butterfield,1 Jaswinder Khattra,1 Jennifer K. Asano,1 Sarah A. Barber,1 Susanna Y. Chan,1 Alison Cloutier,1 Shaun M. Coughlin,1 Doug Freeman,1 Noreen Girn,1 Obi L. Griffith,1 Stephen R. Leach,1 Michael Mayo,1 Helen McDonald,1 Stephen B. Montgomery,1 Pawan K. Pandoh,1 Anca S. Petrescu,1 A. Gordon Robertson,1 Jacqueline E. Schein,1 Asim Siddiqui,1 Duane E. Smailus,1 Jeff M. Stott,1 George S. Yang,1 Francis Plummer,2 Anton Andonov,2 Harvey Artsob,2 Nathalie Bastien,2 Kathy Bernard,2 Timothy F. Booth,2 Donnie Bowness,2 Martin Czub,2 Michael Drebot,2 Lisa Fernando,2 Ramon Flick,2 Michael Garbutt,2 Michael Gray,2 Allen Grolla,2 Steven Jones,2 Heinz Feldmann,2 Adrienne Meyers,2 Amin Kabani,2 Yan Li,2 Susan Normand,2 Ute Stroher,2 Graham A. Tipples,2 Shaun Tyler,2 Robert Vogrig,2 Diane Ward,2 Brynn Watson,2 Robert C. Brunham,3 Mel Krajden,3 Martin Petric,3 Danuta M. Skowronski,3 Chris Upton,4 Rachel L. Roper4

We sequenced the 29,751-base genome of the severe acute respiratory syndrome (SARS)–associated coronavirus known as the Tor2 isolate. The genome sequence reveals that this coronavirus is only moderately related to other known coronaviruses, including two human coronaviruses, HCoV-OC43 and HCoV-229E. Phylogenetic analysis of the predicted viral proteins indicates that the virus does not closely resemble any of the three previously known groups of coronaviruses. The genome sequence will aid in the diagnosis of SARS virus infection in humans and potential animal hosts (using polymerase chain reaction and immunological tests), in the development of antivirals (including neutralizing antibodies), and in the identification of putative epitopes for vaccine development.

1 British Columbia Cancer Agency (BCCA) Genome Sciences Centre, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada.
2 National Microbiology Laboratory, 1015 Arlington Street, Winnipeg, Manitoba R3E 3R2, Canada.
3 British Columbia Centre for Disease Control and University of British Columbia Centre for Disease Control, 655 West 12th Avenue, Vancouver, British Columbia V5Z 4R4, Canada.
4 Department of Biochemistry and Microbiology, University of Victoria, Post Office Box 3055 STN CSC, Victoria, British Columbia V8W 3P6, Canada.

* To whom correspondence should be addressed. E-mail: mmarra{at}bccgsc.ca

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