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The Genome Sequence of the SARS-Associated Coronavirus
Marco A. Marra,1*Steven J. M. Jones,1Caroline R. Astell,1Robert A. Holt,1Angela Brooks-Wilson,1Yaron S. N. Butterfield,1Jaswinder Khattra,1Jennifer K. Asano,1Sarah A. Barber,1Susanna Y. Chan,1Alison Cloutier,1Shaun M. Coughlin,1Doug Freeman,1Noreen Girn,1Obi L. Griffith,1Stephen R. Leach,1Michael Mayo,1Helen McDonald,1Stephen B. Montgomery,1Pawan K. Pandoh,1Anca S. Petrescu,1A. Gordon Robertson,1Jacqueline E. Schein,1Asim Siddiqui,1Duane E. Smailus,1Jeff M. Stott,1George S. Yang,1Francis Plummer,2Anton Andonov,2Harvey Artsob,2Nathalie Bastien,2Kathy Bernard,2Timothy F. Booth,2Donnie Bowness,2Martin Czub,2Michael Drebot,2Lisa Fernando,2Ramon Flick,2Michael Garbutt,2Michael Gray,2Allen Grolla,2Steven Jones,2Heinz Feldmann,2Adrienne Meyers,2Amin Kabani,2Yan Li,2Susan Normand,2Ute Stroher,2Graham A. Tipples,2Shaun Tyler,2Robert Vogrig,2Diane Ward,2Brynn Watson,2Robert C. Brunham,3Mel Krajden,3Martin Petric,3Danuta M. Skowronski,3Chris Upton,4Rachel L. Roper4
We sequenced the 29,751-base genome of the severe acute respiratorysyndrome (SARS)–associated coronavirus known as the Tor2isolate. The genome sequence reveals that this coronavirus isonly moderately related to other known coronaviruses, includingtwo human coronaviruses, HCoV-OC43 and HCoV-229E. Phylogeneticanalysis of the predicted viral proteins indicates that thevirus does not closely resemble any of the three previouslyknown groups of coronaviruses. The genome sequence will aidin the diagnosis of SARS virus infection in humans and potentialanimal hosts (using polymerase chain reaction and immunologicaltests), in the development of antivirals (including neutralizingantibodies), and in the identification of putative epitopesfor vaccine development.
1 British Columbia Cancer Agency (BCCA) Genome Sciences Centre, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada. 2 National Microbiology Laboratory, 1015 Arlington Street, Winnipeg, Manitoba R3E 3R2, Canada. 3 British Columbia Centre for Disease Control and University of British Columbia Centre for Disease Control, 655 West 12th Avenue, Vancouver, British Columbia V5Z 4R4, Canada. 4 Department of Biochemistry and Microbiology, University of Victoria, Post Office Box 3055 STN CSC, Victoria, British Columbia V8W 3P6, Canada.
* To whom correspondence should be addressed. E-mail: mmarra{at}bccgsc.ca
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J. Virol.
80, 7136-7145
|Abstract »|Full Text »|PDF »
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Y. He, J. Li, W. Li, S. Lustigman, M. Farzan, and S. Jiang (2006)
J. Immunol.
176, 6085-6092
|Abstract »|Full Text »|PDF »
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W. Li, S.-K. Wong, F. Li, J. H. Kuhn, I-C. Huang, H. Choe, and M. Farzan (2006)
J. Virol.
80, 4211-4219
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M. D. SORENSEN, B. SORENSEN, R. GONZALEZ-DOSAL, C. J. MELCHJORSEN, J. WEIBEL, J. WANG, C. W. JUN, Y. HUANMING, and P. KRISTENSEN (2006)
Ann. N.Y. Acad. Sci.
1067, 500-505
|Abstract »|Full Text »|PDF »
Specific epitopes of the structural and hypothetical proteins elicit variable humoral responses in SARS patients.
S C S Chow, C Y S Ho, T T Y Tam, C Wu, T Cheung, P K S Chan, M H L Ng, P K Hui, H K Ng, D M Y Au, et al. (2006)
J. Clin. Pathol.
59, 468-476
|Abstract »|Full Text »|PDF »
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S. Hakansson-McReynolds, S. Jiang, L. Rong, and M. Caffrey (2006)
J. Biol. Chem.
281, 11965-11971
|Abstract »|Full Text »|PDF »
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W.-E. Chan, C.-K. Chuang, S.-H. Yeh, M.-S. Chang, and S. S.-L. Chen (2006)
J. Virol.
80, 3225-3237
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L.-H. M. Chu, W.-Y. Choy, S.-N. Tsai, Z. Rao, and S.-M. Ngai (2006)
Protein Sci.
15, 699-709
|Abstract »|Full Text »|PDF »
SARS Coronavirus E Protein in Phospholipid Bilayers: An X-Ray Study.
Z. Khattari, G. Brotons, M. Akkawi, E. Arbely, I. T. Arkin, and T. Salditt (2006)
Biophys. J.
90, 2038-2050
|Abstract »|Full Text »|PDF »
Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirus..
R. H. See, A. N. Zakhartchouk, M. Petric, D. J. Lawrence, C. P. Y. Mok, R. J. Hogan, T. Rowe, L. A. Zitzow, K. P. Karunakaran, M. M. Hitt, et al. (2006)
J. Gen. Virol.
87, 641-650
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M. Maache, F. Komurian-Pradel, A. Rajoharison, M. Perret, J.-L. Berland, S. Pouzol, A. Bagnaud, B. Duverger, J. Xu, A. Osuna, et al. (2006)
Clin. Vaccine Immunol.
13, 409-414
|Abstract »|Full Text »|PDF »
Glycosylation of the Severe Acute Respiratory Syndrome Coronavirus Triple-Spanning Membrane Proteins 3a and M.
M. Oostra, C. A. M. de Haan, R. J. de Groot, and P. J. M. Rottier (2006)
J. Virol.
80, 2326-2336
|Abstract »|Full Text »|PDF »
Pyridine N-oxide derivatives are inhibitory to the human SARS and feline infectious peritonitis coronavirus in cell culture.
J. Balzarini, E. Keyaerts, L. Vijgen, F. Vandermeer, M. Stevens, E. De Clercq, H. Egberink, and M. Van Ranst (2006)
J. Antimicrob. Chemother.
57, 472-481
|Abstract »|Full Text »|PDF »
Serum Proteomic Fingerprints of Adult Patients with Severe Acute Respiratory Syndrome.
R. T.K. Pang, T. C.W. Poon, K.C. A. Chan, N. L.S. Lee, R. W.K. Chiu, Y.-K. Tong, R. M.Y. Wong, S. S.C. Chim, S. M. Ngai, J. J.Y. Sung, et al. (2006)
Clin. Chem.
52, 421-429
|Abstract »|Full Text »|PDF »
Important Role for the Transmembrane Domain of Severe Acute Respiratory Syndrome Coronavirus Spike Protein during Entry.
R. Broer, B. Boson, W. Spaan, F.-L. Cosset, and J. Corver (2006)
J. Virol.
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