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Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome
Paul A. Rota,1*M. Steven Oberste,1Stephan S. Monroe,1W. Allan Nix,1Ray Campagnoli,1Joseph P. Icenogle,1Silvia Peñaranda,1Bettina Bankamp,1Kaija Maher,1Min-hsin Chen,1Suxiong Tong,1Azaibi Tamin,1Luis Lowe,1Michael Frace,1Joseph L. DeRisi,2Qi Chen,1David Wang,2Dean D. Erdman,1Teresa C. T. Peret,1Cara Burns,1Thomas G. Ksiazek,1Pierre E. Rollin,1Anthony Sanchez,1Stephanie Liffick,1Brian Holloway,1Josef Limor,1Karen McCaustland,1Melissa Olsen-Rasmussen,1Ron Fouchier,3Stephan Günther,4Albert D. M. E. Osterhaus,3Christian Drosten,4Mark A. Pallansch,1Larry J. Anderson,1William J. Bellini1
In March 2003, a novel coronavirus (SARS-CoV) was discoveredin association with cases of severe acute respiratorysyndrome(SARS). The sequence of the complete genome of SARS-CoV wasdetermined, and the initial characterization of the viral genomeis presented in this report. The genome of SARS-CoV is 29,727nucleotides in length and has 11 open reading frames, and itsgenome organization is similar to that of other coronaviruses.Phylogenetic analyses and sequence comparisons showed that SARS-CoVis not closelyrelated to anyof the previouslycharacterized coronaviruses.
1 National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. 2 Departments of Biochemistry and Biophysics, University of California–San Francisco, San Francisco, CA 94143, USA. 3 Department of Virology, Erasmus University, Rotterdam, 3000 DR, Netherlands. 4 Department of Virology, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany.
* To whom correspondence should be addressed. E-mail: prota{at}cdc.gov
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