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Science 30 May 2003:
Vol. 300. no. 5624, p. 1337
DOI: 10.1126/science.300.5624.1337l
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This Week in Science

Annotation of DNA sequences containing the sequence UGA is problematic because it serves as a signal for both termination of protein synthesis and as the selenocysteine codon. Kryukov et al. (p. 1439) developed a computational approach to this problem based on structural and thermodynamic information as well as information about evolutionary conservation from sequenced genomes. New mammalian selenoproteins were identified and validated by metabolic labeling; two are localized on the plasma membrane.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)