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Science 9 May 2003:
Vol. 300. no. 5621, p. 861
DOI: 10.1126/science.300.5621.861n
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This Week in Science

Neurons from retinae of the right and left eyes project to different regions of the mature brain's dorsal lateral geniculate nucleus (DLGN). To tease apart the effects of bulk neuronal activity from correlation of neuronal activity, whereby neurons originating from the same eye fire together, Huberman et al. (p. 994) have studied the effects of immunological ablation of amacrine cells in the developing ferret eye. Without the normally interspersed amacrine cells, the ganglion cells of the retina retain activity but lose the tendency to correlate that activity with their near neighbors. Observations of the corresponding DLGN show that the correlated aspect of that activity is not required for eye-specific segregation patterns to develop.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)