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Science 25 April 2003:
Vol. 300. no. 5619, pp. 594 - 595
DOI: 10.1126/science.1083725
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Perspectives

SIGNAL TRANSDUCTION:
Fishing at the Cell Surface

James L. Maller

Some of the cellular effects of steroid hormones are too rapid to be mediated by nuclear steroid receptors that directly alter gene transcription. In his Perspective, Maller discusses new work (published elsewhere) that identifies a distinct class of steroid receptor associated with the plasma membrane. This new class of steroid receptor exerts its effects via cell signaling pathways rather than by direct alteration of gene transcription.

The author is in the Howard Hughes Medical Institute and Department of Pharmacology, University of Colorado School of Medicine, Denver, CO 80262, USA. E-mail: jim.maller{at}uchsc.edu

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