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Science 18 April 2003:
Vol. 300. no. 5618, pp. 442 - 443
DOI: 10.1126/science.1084468
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Perspectives

CANCER:
An Unstable Liaison

Christoph Lengauer

It is well established that changes in the pattern of DNA methylation are involved in tumor formation. But whether hypomethylation or hypermethylation is the culprit is questionable. In his Perspective, Lengauer discusses intriguing new findings providing evidence that hypomethylation contributes to genomic instability leading to cancer.

The author is in the Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. E-mail: lengauer{at}jhmi.edu

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