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Science 11 April 2003:
Vol. 300. no. 5617, pp. 339 - 342
DOI: 10.1126/science.1083317
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Reports

Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

Joseph C. Sun, Michael J. Bevan*

The CD8+ cytotoxic T cell response to pathogens is thought to be CD4+ helper T cell independent because infectious agents provide their own inflammatory signals. Mice that lack CD4+ T cells mount a primary CD8 response to Listeria monocytogenes equal to that of wild-type mice and rapidly clear the infection. However, protective memory to a challenge is gradually lost in the former animals. Memory CD8+ T cells from normal mice can respond rapidly, but memory CD8+ T cells that are generated without CD4 help are defective in their ability to respond to secondary encounters with antigen. The results highlight a previously undescribed role for CD4 help in promoting protective CD8 memory development.

Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
*   To whom correspondence should be addressed: E-mail: mbevan{at}u.washington.edu

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Requirement for CD70 in CD4+ Th Cell-Dependent and Innate Receptor-Mediated CD8+ T Cell Priming..
V. Y. Taraban, T. F. Rowley, D. F. Tough, and A. Al-Shamkhani (2006)
J. Immunol. 177, 2969-2975
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Spontaneous CD4+ T Cell Responses against TRAG-3 in Patients with Melanoma and Breast Cancers.
B. Janjic, P. Andrade, X.-F. Wang, J. Fourcade, C. Almunia, P. Kudela, A. Brufsky, S. Jacobs, D. Friedland, R. Stoller, et al. (2006)
J. Immunol. 177, 2717-2727
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Antigen targeting to endosomal pathway in dendritic cell vaccination activates regulatory T cells and attenuates tumor immunity.
M. Maksimow, M. Miiluniemi, F. Marttila-Ichihara, S. Jalkanen, and A. Hanninen (2006)
Blood 108, 1298-1305
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