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Science 11 April 2003:
Vol. 300. no. 5617, pp. 294 - 295
DOI: 10.1126/science.1083395
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Viewpoint
From Knowing to Controlling: A Path from Genomics to Drugs Using Small Molecule Probes
Robert L. Strausberg,1*
Stuart L. Schreiber2
The National Cancer Institute Initiative in Chemical Genetics is
designed to encourage the development of small molecular probes. The
probes are useful for activating or inactivating protein functions,
thereby providing resources that help discern the functions of gene
products in normal and disease cells, as well as in tissues. This
initiative includes "ChemBank," a suite of informatics tools and
databases aimed at promoting the development and use of chemical genetics by scientists worldwide. The information generated with such
tools should provide a critical link from genomic discovery to drug
development.
1 Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Bethesda, MD 20892, USA.
2 Howard Hughes Medical Institute, Department of Chemistry
and Chemical Biology, Harvard University, Cambridge, MA 02115, USA.
*
To whom correspondence should be addressed. E-mail:
RLS{at}nih.gov
Read the Full Text
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Plant Physiology
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