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Science 11 April 2003:
Vol. 300. no. 5617, pp. 286 - 290
DOI: 10.1126/science.1084564
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Viewpoint

The Human Genome Project: Lessons from Large-Scale Biology

Francis S. Collins,1* Michael Morgan,2 Aristides Patrinos3

The Human Genome Project has been the first major foray of the biological and medical research communities into "big science." In this Viewpoint, we present some of our experiences in organizing and managing such a complicated, publicly funded, international effort. We believe that many of the lessons we learned will be applicable to future large-scale projects in biology.

1 National Human Genome Research Institute, National Institutes of Health, Building 31, Room 4B09, 9000 Rockville Pike, Bethesda, MD 20892, USA.
2 The Wellcome Trust, 183 Easton Road, London NW1 2BE, England.
3 U.S. Department of Energy, 1000 Independence Avenue, S.W., Washington, DC 20585, USA.
*   To whom correspondence should be addressed. E-mail: fc23a{at}nih.gov

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