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Even with the availability of the genome sequences of many different organisms, we are still left wondering about the definition of a true gene. In their Perspective, Snyder and Gerstein discuss different criteria that can be used to define what a gene is in the era of genomics.
M. Snyder is in the Department of Molecular, Cellular, and Developmental Biology, and both authors are in the Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
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