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Science 21 March 2003:
Vol. 299. no. 5614, pp. 1856 - 1858
DOI: 10.1126/science.1083627
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Perspectives

NEUROSCIENCE:
Gambling on Dopamine

Peter Shizgal and Andreas Arvanitogiannis

Midbrain dopamine neurons are important for motor control, motivation, effort, reward, analgesia, stress, learning, attention, and cognition. In a Perspective, Shizgal and Arvanitogiannis explore new findings (Fiorillo et al.) revealing a gradual increase in the firing rate of midbrain dopamine neurons in anticipation of uncertain rewards. This firing pattern may serve to heighten attention during uncertainty, thus promoting the learning of better predictors of reward.

The authors are at the Center for Studies in Behavioral Neurobiology, Concordia University, Montréal, Quebec, H3G 1M8, Canada. E-mail: shizgal{at}csbn.concordia.ca; andreas{at}csbn.concordia.ca

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Pathological Gambling Caused by Drugs Used to Treat Parkinson Disease.
M. L. Dodd, K. J. Klos, J. H. Bower, Y. E. Geda, K. A. Josephs, and J. E. Ahlskog (2005)
Arch Neurol 62, 1377-1381
   Abstract »    Full Text »    PDF »
Doctoral Preparation of Scientifically Based Education Researchers.
M. Eisenhart and R. L. DeHaan (2005)
Educational Researcher 34, 3-13
   Abstract »    PDF »
Hyperdopaminergic Mutant Mice Have Higher "Wanting" But Not "Liking" for Sweet Rewards.
S. Pecina, B. Cagniard, K. C. Berridge, J. W. Aldridge, and X. Zhuang (2003)
J. Neurosci. 23, 9395-9402
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)