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Science 7 March 2003:
Vol. 299. no. 5612, pp. 1575 - 1578
DOI: 10.1126/science.1077905
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Reports

STAT1-Dependent Innate Immunity to a Norwalk-Like Virus

Stephanie M. Karst,* Christiane E. Wobus,* Margarita Lay, John Davidson, Herbert W. Virgin IVdagger

Norwalk-like caliciviruses (Noroviruses) cause over 90% of nonbacterial epidemic gastroenteritis worldwide, but the pathogenesis of norovirus infection is poorly understood because these viruses do not grow in cultured cells and there is no small animal model. Here, we report a previously unknown murine norovirus. Analysis of Murine Norovirus 1 infection revealed that signal transducer and activator of transcription 1-dependent innate immunity, but not T and B cell-dependent adaptive immunity, is essential for norovirus resistance. The identification of host molecules essential for murine norovirus resistance may provide targets for prevention or control of an important human disease.

Department of Pathology and Immunology, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: Virgin{at}immunology.wustl.edu

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