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Science 28 February 2003:
Vol. 299. no. 5611, pp. 1327 - 1328
DOI: 10.1126/science.1082717
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Perspectives

IMMUNOLOGY:
Isomeric Antibodies

Jefferson Foote

Generating an incredibly diverse repertoire of antibodies is not a problem for the humoral immune system. Yet, as Foote comments in his Perspective, the humoral immune system has chosen to broaden its antibody repertoire still further. It turns out that the same antibody can exist as two conformational isomers that bind to structurally different antigens (James et al.).

The author is at the Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. E-mail: jfoote{at}fhcrc.org

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Protein-bound 4-Hydroxy-2-nonenal: AN ENDOGENOUS TRIGGERING ANTIGEN OF ANTI-DNA RESPONSE.
K. Toyoda, R. Nagae, M. Akagawa, K. Ishino, T. Shibata, S. Ito, N. Shibata, T. Yamamoto, M. Kobayashi, Y. Takasaki, et al. (2007)
J. Biol. Chem. 282, 25769-25778
   Abstract »    Full Text »    PDF »
Quantitatively Reduced Participation of Anti-Nuclear Antigen B Cells That Down-Regulate B Cell Receptor during Primary Development in the Germinal Center/Memory B Cell Response to Foreign Antigen.
B. Alabyev, Z. S. M. Rahman, and T. Manser (2007)
J. Immunol. 178, 5623-5634
   Abstract »    Full Text »    PDF »
Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the Fc{epsilon}RI.
J. Kitaura, J. Song, M. Tsai, K. Asai, M. Maeda-Yamamoto, A. Mocsai, Y. Kawakami, F.-T. Liu, C. A. Lowell, B. G. Barisas, et al. (2003)
PNAS 100, 12911-12916
   Abstract »    Full Text »    PDF »
The specificity of cross-reactivity: Promiscuous antibody binding involves specific hydrogen bonds rather than nonspecific hydrophobic stickiness.
L. C. James and D. S. Tawfik (2003)
Protein Sci. 12, 2183-2193
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)