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Originally published in Science Express on 9 January 2003
Science 14 February 2003: Vol. 299. no. 5609, pp. 1057 - 1061
DOI: 10.1126/science.1079490
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Reports
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Shohei Hori,1
Takashi Nomura,2
Shimon Sakaguchi12*
Regulatory T cells engage in the maintenance of
immunological self-tolerance by actively suppressing self-reactive
lymphocytes. Little is known, however, about the molecular mechanism of
their development. Here we show that Foxp3, which encodes a
transcription factor that is genetically defective in an autoimmune and
inflammatory syndrome in humans and mice, is specifically expressed in
naturally arising CD4+ regulatory T cells. Furthermore,
retroviral gene transfer of Foxp3 converts naïve T
cells toward a regulatory T cell phenotype similar to that of naturally
occurring CD4+ regulatory T cells. Thus, Foxp3
is a key regulatory gene for the development of regulatory T cells.
1 Laboratory of Immunopathology, Research
Center for Allergy and Immunology, Institute for Physical and Chemical
Research, Yokohama 230-0045, Japan.
2 Department of
Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto
University, Kyoto 606-8507, Japan.
*
To whom correspondence should be addressed. E-mail:
shimon{at}frontier.kyoto-u.ac.jp
Read the Full Text
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- Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero.
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Science
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- Retinal Pigment Epithelium-Derived CTLA-2{alpha} Induces TGF{beta}-Producing T Regulatory Cells.
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- Increased Foxp3+ CD4+ Regulatory T Cells with Intact Suppressive Activity but Altered Cellular Localization in Murine Lupus.
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173, 1682-1692
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- Cancer and Immune Response: Old and New Evidence for Future Challenges.
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Oncologist
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- CD4+CD25+ Foxp3+ Regulatory T Cells Protect against T Cell-Mediated Fulminant Hepatitis in a TGF-{beta}-Dependent Manner in Mice.
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181, 7221-7229
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- Dendritic Cells Genetically Engineered to Express IL-10 Induce Long-Lasting Antigen-Specific Tolerance in Experimental Asthma.
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- Recent thymic origin, differentiation, and turnover of regulatory T cells.
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- Impact of Protective IL-2 Allelic Variants on CD4+Foxp3+ Regulatory T Cell Function In Situ and Resistance to Autoimmune Diabetes in NOD Mice.
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- Foxp3+ T-Regulatory Cells in Sjogren's Syndrome: Correlation with the Grade of the Autoimmune Lesion and Certain Adverse Prognostic Factors.
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- Thymus Exosomes-Like Particles Induce Regulatory T Cells.
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181, 5242-5248
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- Spontaneous Colitis Occurrence in Transgenic Mice with Altered B7-Mediated Costimulation.
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322, 271-275
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- Update in Endocrine Autoimmunity.
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84, 973-980
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- Regulatory T Cells Prevent Transfer of Type 1 Diabetes in NOD Mice Only When Their Antigen Is Present In Vivo.
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