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Toll Pathway-Dependent Blockade of CD4+CD25+ T Cell-Mediated Suppression by Dendritic Cells
Chandrashekhar Pasare,Ruslan Medzhitov*
Toll-like receptors (TLRs) control activation of adaptive immune
responses by antigen-presenting cells (APCs). However, initiationof
adaptive immune responses is also controlled by regulatoryT cells
(TR cells), which act to prevent activation of
autoreactiveT cells. Here we describe a second mechanism of immune
inductionby TLRs, which is independent of effects on costimulation.
Microbialinduction of the Toll pathway blocked the suppressive effect
ofCD4+CD25+ TR cells, allowing
activation of pathogen-specific adaptive immuneresponses. This block
of suppressor activity was dependent inpart on interleukin-6, which
was induced by TLRs upon recognitionof microbial products.
Howard Hughes Medical Institute and Section of Immunobiology, Yale
University School of Medicine, New Haven, CT 06520, USA.
*
To whom correspondence should be addressed. E-mail:
ruslan.medzhitov{at}yale.edu
Fiona Powrie and Kevin J. Maloy (14 February 2003) Science299 (5609), 1030.
[DOI: 10.1126/science.1082031] |Summary »|Full Text »|PDF »
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R. Sutmuller, A. Garritsen, and G. J Adema (2007)
Ann Rheum Dis
66, iii91-iii95
|Abstract »|Full Text »|PDF »
A Link between PDL1 and T Regulatory Cells in Fetomaternal Tolerance.
A. Habicht, S. Dada, M. Jurewicz, B. T. Fife, H. Yagita, M. Azuma, M. H. Sayegh, and I. Guleria (2007)
J. Immunol.
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|Abstract »|Full Text »|PDF »
T Regulatory Cells Control Numbers of NK Cells and CD8{alpha}+ Immature Dendritic Cells in the Lymph Node Paracortex.
M. Giroux, E. Yurchenko, J. St.-Pierre, C. A. Piccirillo, and C. Perreault (2007)
J. Immunol.
179, 4492-4502
|Abstract »|Full Text »|PDF »
The Type 1 Diabetes Locus Idd6 Controls TLR1 Expression.
D. Vallois, C. H. Grimm, P. Avner, C. Boitard, and U. C. Rogner (2007)
J. Immunol.
179, 3896-3903
|Abstract »|Full Text »|PDF »
Toll-like Receptors in Tumor Immunotherapy.
C. M. Paulos, A. Kaiser, C. Wrzesinski, C. S. Hinrichs, L. Cassard, A. Boni, P. Muranski, L. Sanchez-Perez, D. C. Palmer, Z. Yu, et al. (2007)
Clin. Cancer Res.
13, 5280-5289
|Abstract »|Full Text »|PDF »
