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Science 10 January 2003:
Vol. 299. no. 5604, p. 161
DOI: 10.1126/science.299.5604.161o
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In Parkinson's disease, motor abnormalities develop as dopaminergic neurons of the nigrostriatal pathway in the brain die. Bonifati et al. (p. 256) identify mutations in a gene called DJ-1 in an Italian and a Dutch family with an early-onset autosomal recessive form of Parkinson's disease. Although the function of DJ-1, a ubiquitously expressed and highly conserved protein, is unknown, there is indirect evidence that it is involved in the cell's response to oxidative stress.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)