Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 3 January 2003:
Vol. 299. no. 5603, pp. 117 - 120
DOI: 10.1126/science.1076647
Prev | Table of Contents | Next

Reports

Pregnancy-Stimulated Neurogenesis in the Adult Female Forebrain Mediated by Prolactin

Tetsuro Shingo,* Christopher Gregg, Emeka Enwere, Hirokazu Fujikawa, Rozina Hassam, Colleen Geary, James C. Cross, Samuel Weissdagger

Neurogenesis occurs in the olfactory system of the adult brain throughout life, in both invertebrates and vertebrates, but its physiological regulation is not understood. We show that the production of neuronal progenitors is stimulated in the forebrain subventricular zone of female mice during pregnancy and that this effect is mediated by the hormone prolactin. The progenitors then migrate to produce new olfactory interneurons, a process likely to be important for maternal behavior, because olfactory discrimination is critical for recognition and rearing of offspring. Neurogenesis occurs even in females that mate with sterile males. These findings imply that forebrain olfactory neurogenesis may contribute to adaptive behaviors in mating and pregnancy.

Genes & Development Research Group, Department of Cell Biology and Anatomy and Department of Biochemistry and Molecular Biology, University of Calgary Faculty of Medicine, Calgary, Alberta, Canada T2N 4N1.
*   Present address: Department of Neurological Surgery, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.

dagger    To whom correspondence should be addressed. E-mail: weiss{at}ucalgary.ca

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Prolactin Activates Mitogen-Activated Protein Kinase Signaling and Corticotropin Releasing Hormone Transcription in Rat Hypothalamic Neurons.
A. Blume, L. Torner, Y. Liu, S. Subburaju, G. Aguilera, and I. D. Neumann (2009)
Endocrinology 150, 1841-1849
   Abstract »    Full Text »    PDF »
Prolactin Receptor Is Required for Normal Glucose Homeostasis and Modulation of {beta}-Cell Mass during Pregnancy.
C. Huang, F. Snider, and J. C. Cross (2009)
Endocrinology 150, 1618-1626
   Abstract »    Full Text »    PDF »
Prolactin Prevents Chronic Stress-Induced Decrease of Adult Hippocampal Neurogenesis and Promotes Neuronal Fate.
L. Torner, S. Karg, A. Blume, M. Kandasamy, H.-G. Kuhn, J. Winkler, L. Aigner, and I. D. Neumann (2009)
J. Neurosci. 29, 1826-1833
   Abstract »    Full Text »    PDF »
Brain-Derived Neurotrophic Factor Signaling Does Not Stimulate Subventricular Zone Neurogenesis in Adult Mice and Rats.
R. P. Galvao, J. M. Garcia-Verdugo, and A. Alvarez-Buylla (2008)
J. Neurosci. 28, 13368-13383
   Abstract »    Full Text »    PDF »
Stem Cells, Their Niches and the Systemic Environment: An Aging Network.
D. Drummond-Barbosa (2008)
Genetics 180, 1787-1797
   Abstract »    Full Text »    PDF »
Estrous cycle, pregnancy, and parity enhance performance of rats in object recognition or object placement tasks.
J. J Paris and C. A Frye (2008)
Reproduction 136, 105-115
   Abstract »    Full Text »    PDF »
Regulation of electrolyte transport across cultured endometrial epithelial cells by prolactin.
C. Deachapunya, S. Poonyachoti, and N. Krishnamra (2008)
J. Endocrinol. 197, 575-582
   Abstract »    Full Text »    PDF »
Long-Term, Homologous Prolactin, Administered through Ectopic Pituitary Grafts, Induces Hypothalamic Dopamine Neuron Differentiation in Adult Snell Dwarf Mice.
C. E. Khodr, S. M. Clark, D. L. Hurley, and C. J. Phelps (2008)
Endocrinology 149, 2010-2018
   Abstract »    Full Text »    PDF »
Withdrawal from Cocaine Self-Administration Normalizes Deficits in Proliferation and Enhances Maturity of Adult-Generated Hippocampal Neurons.
M. A. Noonan, K. H. Choi, D. W. Self, and A. J. Eisch (2008)
J. Neurosci. 28, 2516-2526
   Abstract »    Full Text »    PDF »
Menin Controls Growth of Pancreatic {beta}-Cells in Pregnant Mice and Promotes Gestational Diabetes Mellitus.
S. K. Karnik, H. Chen, G. W. McLean, J. J. Heit, X. Gu, A. Y. Zhang, M. Fontaine, M. H. Yen, and S. K. Kim (2007)
Science 318, 806-809
   Abstract »    Full Text »    PDF »
Subventricular Zone Stem Cells Are Heterogeneous with Respect to Their Embryonic Origins and Neurogenic Fates in the Adult Olfactory Bulb.
K. M. Young, M. Fogarty, N. Kessaris, and W. D. Richardson (2007)
J. Neurosci. 27, 8286-8296
   Abstract »    Full Text »    PDF »
Understanding the Regulation and Function of Adult Neurogenesis: Contribution from an Insect Model, the House Cricket.
M. Cayre, S. Scotto-Lomassese, J. Malaterre, C. Strambi, and A. Strambi (2007)
Chem Senses 32, 385-395
   Abstract »    Full Text »    PDF »
Control of Early Events in Olfactory Processing by Adult Neurogenesis.
G. Gheusi and P.-M. Lledo (2007)
Chem Senses 32, 397-409
   Abstract »    Full Text »    PDF »
White Matter Plasticity and Enhanced Remyelination in the Maternal CNS.
C. Gregg, V. Shikar, P. Larsen, G. Mak, A. Chojnacki, V. W. Yong, and S. Weiss (2007)
J. Neurosci. 27, 1812-1823
   Abstract »    Full Text »    PDF »
Reproductive role of prolactin.
A. Bachelot and N. Binart (2007)
Reproduction 133, 361-369
   Abstract »    Full Text »    PDF »
High Levels of New Neuron Addition Persist When the Sensitive Period for Song Learning Is Experimentally Prolonged.
L. Wilbrecht, H. Williams, N. Gangadhar, and F. Nottebohm (2006)
J. Neurosci. 26, 9135-9141
   Abstract »    Full Text »    PDF »
Prolactin Modulates TRPV1 in Female Rat Trigeminal Sensory Neurons.
A. Diogenes, A. M. Patwardhan, N. A. Jeske, N. B. Ruparel, V. Goffin, A. N. Akopian, and K. M. Hargreaves (2006)
J. Neurosci. 26, 8126-8136
   Abstract »    Full Text »    PDF »
A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells.
M. Sakaguchi, T. Shingo, T. Shimazaki, H. J. Okano, M. Shiwa, S. Ishibashi, H. Oguro, M. Ninomiya, T. Kadoya, H. Horie, et al. (2006)
PNAS 103, 7112-7117
   Abstract »    Full Text »    PDF »
Running in pregnancy transiently increases postnatal hippocampal neurogenesis in the offspring.
A. Bick-Sander, B. Steiner, S. A. Wolf, H. Babu, and G. Kempermann (2006)
PNAS 103, 3852-3857
   Abstract »    Full Text »    PDF »
cAMP Response Element-Binding Protein Regulates Differentiation and Survival of Newborn Neurons in the Olfactory Bulb.
C. Giachino, S. De Marchis, C. Giampietro, R. Parlato, I. Perroteau, G. Schutz, A. Fasolo, and P. Peretto (2005)
J. Neurosci. 25, 10105-10118
   Abstract »    Full Text »    PDF »
Adult Neurogenesis: From Precursors to Network and Physiology.
D. N. Abrous, M. Koehl, and M. Le Moal (2005)
Physiol Rev 85, 523-569
   Abstract »    Full Text »    PDF »
Information Processing in the Mammalian Olfactory System.
P.-M. Lledo, G. Gheusi, and J.-D. Vincent (2005)
Physiol Rev 85, 281-317
   Abstract »    Full Text »    PDF »
Neurogenesis of corticospinal motor neurons extending spinal projections in adult mice.
J. Chen, S. S. P. Magavi, and J. D. Macklis (2004)
PNAS 101, 16357-16362
   Abstract »    Full Text »    PDF »
Roles and Regulation of Stat Family Transcription Factors in Human Breast Cancer.
C. V. Clevenger (2004)
Am. J. Pathol. 165, 1449-1460
   Abstract »    Full Text »    PDF »
Aging Results in Reduced Epidermal Growth Factor Receptor Signaling, Diminished Olfactory Neurogenesis, and Deficits in Fine Olfactory Discrimination.
E. Enwere, T. Shingo, C. Gregg, H. Fujikawa, S. Ohta, and S. Weiss (2004)
J. Neurosci. 24, 8354-8365
   Abstract »    Full Text »    PDF »
p107 regulates neural precursor cells in the mammalian brain.
J. L. Vanderluit, K. L. Ferguson, V. Nikoletopoulou, M. Parker, V. Ruzhynsky, T. Alexson, S. M. McNamara, D. S. Park, M. Rudnicki, and R. S. Slack (2004)
J. Cell Biol. 166, 853-863
   Abstract »    Full Text »    PDF »
Generation of Functional Radial Glial Cells by Embryonic and Adult Forebrain Neural Stem Cells.
C. Gregg and S. Weiss (2003)
J. Neurosci. 23, 11587-11601
   Abstract »    Full Text »    PDF »
Comparison of the genomes of human and mouse lays the foundation of genome zoology.
R. D. Emes, L. Goodstadt, E. E. Winter, and C. P. Ponting (2003)
Hum. Mol. Genet. 12, 701-709
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)