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Science 20 December 2002:
Vol. 298. no. 5602, pp. 2392 - 2395
DOI: 10.1126/science.1076963
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Reports

A Distinct Signaling Pathway Used by the IgG-Containing B Cell Antigen Receptor

Chisato Wakabayashi,1* Takahiro Adachi,1* Jürgen Wienands,2dagger Takeshi Tsubata1ddagger

The immunoglobulin G (IgG)-containing B lymphocyte antigen receptor (IgG-BCR) transmits a signal distinct from that of IgM-BCR or IgD-BCR, although all three use the same signal-transducing component, Igalpha /Igbeta . Here we demonstrate that the inhibitory coreceptor CD22 down-modulates signaling through IgM-BCR and IgD-BCR, but not that through IgG-BCR, because of the IgG cytoplasmic tail, which prevents CD22 phosphorylation. These results suggest that the cytoplasmic tail of IgG specifically enhances IgG-BCR signaling by preventing CD22-mediated signal inhibition. Enhanced signaling through IgG-BCR may be involved in efficient IgG production, which is crucial for immunity to pathogens.

1 Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, 113-8510 Tokyo, Japan.
2 Department of Molecular Immunology, Biology III, Freiburg University and Max-Planck-Institute for Immunobiology, D-79108 Freiburg, Germany.
*   These authors contributed equally to this work.

dagger    Present address: Department of Biochemistry and Molecular Immunology, University of Bielefeld, D-33615 Bielefeld, Germany.

ddagger    To whom correspondence should be addressed. E-mail: tsubata.imm{at}mri.tmd.ac.jp

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