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Science 20 December 2002:
Vol. 298. no. 5602, pp. 2378 - 2381
DOI: 10.1126/science.1078273
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Reports

Control of Facial Muscle Development by MyoR and Capsulin

Jian-rong Lu,1 Rhonda Bassel-Duby,1 April Hawkins,1 Priscilla Chang,1 Renee Valdez,1 Hai Wu,1 Lin Gan,4 John M. Shelton,2 James A. Richardson,13 Eric N. Olson1*

Members of the MyoD family of basic helix-loop-helix (bHLH) transcription factors control the formation of all skeletal muscles in vertebrates, but little is known of the molecules or mechanisms that confer unique identities to different types of skeletal muscles. MyoR and capsulin are related bHLH transcription factors expressed in specific facial muscle precursors. We show that specific facial muscles are missing in mice lacking both MyoR and capsulin, reflecting the absence of MyoD family gene expression and ablation of the corresponding myogenic lineages. These findings identify MyoR and capsulin as unique transcription factors for the development of specific head muscles.

1 Department of Molecular Biology,
2 Department of Internal Medicine, and
3 Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390-9148, USA.
4 Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA
*   To whom correspondence should be addressed. E-mail: eolson{at}hamon.swmed.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)