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Science 20 December 2002:
Vol. 298. no. 5602, p. 2279
DOI: 10.1126/science.298.5602.2279o
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Levinson et al. (Reports, 26 April 2002, p. 739) conducted a multicenter study of 779 families with schizophrenia and found no evidence of genetic linkage to chromosome 1q--contrary to several previous reports implicating this region in the disease. In separate comments, Macgregor et al. and Bassett et al. assert that locus heterogeniety can explain the divergent results and that failure to replicate linkage may indicate more about the relative merit of different study designs than about the genetics of schizophrenia. Levinson et al. respond that although schizophrenia susceptibility genes may exist on 1q, classical heterogeneity cannot explain a substantial portion of disease cases. They further emphasize the importance of large, multicenter linkage studies to help confirm and localize the multiple interacting loci likely to be involved in schizophrenia.

The full text of these comments can be seen at www.sciencemag.org/cgi/content/full/298/5602/2277a




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