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IMMUNOLOGY: Catalytic Antibody Bridges Innate and Adaptive Immunity
Carl Nathan
Neutrophils of the innate immune system are well equipped to kill invading pathogens by generating a variety of reactive oxygen intermediates including singlet oxygen. In his Perspective, Nathan discusses the surprising finding (Wentworthet al.) that stalwart members of the acquired immune system, the antibodies produced by B cells, can contribute to this armamentarium by catalytically reacting singlet oxygen with water to produce hydrogen peroxide and a powerful ozone-like oxidant, O3.
The author is in the Department of Microbiology and Immunology and Graduate Programs in Immunology and Molecular Biology, Weill Medical College of Cornell University, New York, NY 10021, USA. E-mail: cnathan{at}med.cornell.edu
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[DOI: 10.1126/science.1077642] |Abstract »|Full Text »|PDF »|Supporting Online Material »
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