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Science 13 December 2002:
Vol. 298. no. 5601, p. 2087
DOI: 10.1126/science.298.5601.2087r
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Splicing of pre-messenger RNAs (pre-mRNAs) results in the excision of introns (non-coding regions) and the joining of exons (protein-coding sequences) to yield a translatable mRNA. This process requires five large RNA-protein complexes (called U snRNPs) and a host of associated factors. Makarov et al. (p. 2205) have isolated two complexes: one a new intermediate poised to execute the first step of the reaction, and the other likely a post-splicing recycling product. They characterize these complexes by mass spectrometry and use a comparative analysis of the changing complement of proteins to draw inferences about structural rearrangements in the spliceosome.




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