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Science 6 December 2002:
Vol. 298. no. 5600, pp. 1959 - 1964
DOI: 10.1126/science.1072165
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Review

Molecular Mechanisms of Axon Guidance

Barry J. Dickson

Axons are guided along specific pathways by attractive and repulsive cues in the extracellular environment. Genetic and biochemical studies have led to the identification of highly conserved families of guidance molecules, including netrins, Slits, semaphorins, and ephrins. Guidance cues steer axons by regulating cytoskeletal dynamics in the growth cone through signaling pathways that are still only poorly understood. Elaborate regulatory mechanisms ensure that a given cue elicits the right response from the right axons at the right time but is otherwise ignored. With such regulatory mechanisms in place, a relatively small number of guidance factors can be used to generate intricate patterns of neuronal wiring.

Research Institute of Molecular Pathology, Dr. Bohr-gasse 7, A-1030 Vienna, Austria. E-mail: dickson{at}nt.imp.univie.ac.at

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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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roundabout4 is essential for angiogenesis in vivo.
V. M. Bedell, S.-Y. Yeo, K. W. Park, J. Chung, P. Seth, V. Shivalingappa, J. Zhao, T. Obara, V. P. Sukhatme, I. A. Drummond, et al. (2005)
PNAS 102, 6373-6378
   Abstract »    Full Text »    PDF »
Neural guidance molecules regulate vascular remodeling and vessel navigation.
A. Eichmann, T. Makinen, and K. Alitalo (2005)
Genes & Dev. 19, 1013-1021
   Abstract »    Full Text »    PDF »
Deleted in Colorectal Cancer Binding Netrin-1 Mediates Cell Substrate Adhesion and Recruits Cdc42, Rac1, Pak1, and N-WASP into an Intracellular Signaling Complex That Promotes Growth Cone Expansion.
M. Shekarabi, S. W. Moore, N. X. Tritsch, S. J. Morris, J.-F. Bouchard, and T. E. Kennedy (2005)
J. Neurosci. 25, 3132-3141
   Abstract »    Full Text »    PDF »
Role of neural guidance signals in blood vessel navigation.
M. Autiero, F. De Smet, F. Claes, and P. Carmeliet (2005)
Cardiovasc Res 65, 629-638
   Abstract »    Full Text »    PDF »


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