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Science 6 December 2002:
Vol. 298. no. 5600, pp. 1959 - 1964
DOI: 10.1126/science.1072165
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Review

Molecular Mechanisms of Axon Guidance

Barry J. Dickson

Axons are guided along specific pathways by attractive and repulsive cues in the extracellular environment. Genetic and biochemical studies have led to the identification of highly conserved families of guidance molecules, including netrins, Slits, semaphorins, and ephrins. Guidance cues steer axons by regulating cytoskeletal dynamics in the growth cone through signaling pathways that are still only poorly understood. Elaborate regulatory mechanisms ensure that a given cue elicits the right response from the right axons at the right time but is otherwise ignored. With such regulatory mechanisms in place, a relatively small number of guidance factors can be used to generate intricate patterns of neuronal wiring.

Research Institute of Molecular Pathology, Dr. Bohr-gasse 7, A-1030 Vienna, Austria. E-mail: dickson{at}nt.imp.univie.ac.at

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F. Tang and K. Kalil (2005)
J. Neurosci. 25, 6702-6715
   Abstract »    Full Text »    PDF »
Dendritic cell function in mice lacking Plexin C1.
T. Walzer, L. Galibert, and T. De Smedt (2005)
Int. Immunol. 17, 943-950
   Abstract »    Full Text »    PDF »
A GFP-based genetic screen reveals mutations that disrupt the architecture of the zebrafish retinotectal projection.
T. Xiao, T. Roeser, W. Staub, and H. Baier (2005)
Development 132, 2955-2967
   Abstract »    Full Text »    PDF »
The Actin-Binding Protein UNC-115/abLIM Controls Formation of Lamellipodia and Filopodia and Neuronal Morphogenesis in Caenorhabditis elegans.
Y. Yang and E. A. Lundquist (2005)
Mol. Cell. Biol. 25, 5158-5170
   Abstract »    Full Text »    PDF »
Novel brain wiring functions for classical morphogens: a role as graded positional cues in axon guidance.
F. Charron and M. Tessier-Lavigne (2005)
Development 132, 2251-2262
   Abstract »    Full Text »    PDF »


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