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Science 6 December 2002:
Vol. 298. no. 5600, pp. 1905 - 1907
DOI: 10.1126/science.1079225
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Perspectives

MOLECULAR BIOLOGY:
Untangling Checkpoints

Noriyuki Sagata

In response to genotoxic stresses that damage DNA, cells halt at a series of checkpoints during the cell cycle to provide sufficient time for the DNA to be repaired. In a Perspective, Sagata discusses a new study published elsewhere that shows how the kinase Chk1 contributes to S and G2 checkpoints by phosphorylating a key checkpoint phosphatase, Cdc25A.

The author is in the Department of Biology, Kyushu University, Fukuoka 812-8581, Japan. E-mail: nsagascb{at}mbox.nc.kyushu-u.ac.jp

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Arsenite Slows S Phase Progression via Inhibition of cdc25A Dual Specificity Phosphatase Gene Transcription.
G. M. Lehmann and M. J. McCabe Jr (2007)
Toxicol. Sci. 99, 70-78
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Heat shock protein 90 inhibition sensitizes acute myelogenous leukemia cells to cytarabine.
R. A. Mesa, D. Loegering, H. L. Powell, K. Flatten, S. J. H. Arlander, N. T. Dai, M. P. Heldebrant, B. T. Vroman, B. D. Smith, J. E. Karp, et al. (2005)
Blood 106, 318-327
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{beta}-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases.
Y. Kanemori, K. Uto, and N. Sagata (2005)
PNAS 102, 6279-6284
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The Role of Checkpoint Kinase 1 in Sensitivity to Topoisomerase I Poisons.
K. Flatten, N. T. Dai, B. T. Vroman, D. Loegering, C. Erlichman, L. M. Karnitz, and S. H. Kaufmann (2005)
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Rad9 Protects Cells from Topoisomerase Poison-induced Cell Death.
D. Loegering, S. J. H. Arlander, J. Hackbarth, B. T. Vroman, P. Roos-Mattjus, K. M. Hopkins, H. B. Lieberman, L. M. Karnitz, and S. H. Kaufmann (2004)
J. Biol. Chem. 279, 18641-18647
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Central Role of Fas-associated Death Domain Protein in Apoptosis Induction by the Mitogen-activated Protein Kinase Kinase Inhibitor CI-1040 (PD184352) in Acute Lymphocytic Leukemia Cells in Vitro.
X. W. Meng, J. Chandra, D. Loegering, K. Van Becelaere, T. J. Kottke, S. D. Gore, J. E. Karp, J. Sebolt-Leopold, and S. H. Kaufmann (2003)
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A novel domain in the protein kinase SOS2 mediates interaction with the protein phosphatase 2C ABI2.
M. Ohta, Y. Guo, U. Halfter, and J.-K. Zhu (2003)
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