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Science 6 December 2002:
Vol. 298. no. 5600, pp. 1901 - 1903
DOI: 10.1126/science.1079853
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Perspectives

DEVELOPMENT:
A Tail of Transdifferentiation

David L. Stocum

Salamanders have the enviable ability of being able to regenerate an amputated limb or tail. These amphibians have proven to be a valuable model of tissue regeneration. In his Perspective, Stocum discusses the first unequivocal evidence that salamander tail regeneration involves the ability of neural precusor cells of ectodermal origin to transdifferentiate into mesodermal cell types.

The author is in the Department of Biology and Center for Regenerative Biology and Medicine, School of Science, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, USA. E-mail: dstocum{at}iupui.edu

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