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Science 6 December 2002:
Vol. 298. no. 5600, p. 1843
DOI: 10.1126/science.298.5600.1843j
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This Week in Science

Many recent experiments on stem cells have focused on whether their differentiative capabilities allow switching of their developmental lineages. Echeverri and Tanaka (p. 1993; see the Perspective by Stocum) now follow the fate of stem cells in the relatively normal context of a regenerating salamander tail. Using real-time, live observation of individually labeled cells, the authors find that cells labeled in the spinal cord contribute to muscle and cartilage of the regenerating tail, as well as to more neuronal cells. Although amphibians show a greater capacity to regenerate limb and tail than do mammals, these observations of amphibian cell plasticity may lead to insights into the factors that control mammalian cell plasticity.

Figure 2
CREDIT: ECHEVERRI AND TANAKA




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Science. ISSN 0036-8075 (print), 1095-9203 (online)