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Science 22 November 2002:
Vol. 298. no. 5598, pp. 1567 - 1568
DOI: 10.1126/science.1080001
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Essays on Science and Society

ESSAY: AMERSHAM BIOSCIENCES AND SCIENCE PRIZE:
PAS Domains and Metabolic Status Signaling

Jared Rutter

PAS domains are sensor modules in bacterial two-component regulatory systems, but are also present in diverse eukaryotic proteins. In his essay that won the Amersham Biosciences and Science Grand Prize, Jared Rutter describes how metabolite sensing by PAS domains allows essential cellular processes like circadian rhythm, protein synthesis and sugar storage to be regulated by cellular metabolism.

The author is at the University of Texas Southwestern Medical Center, Houston, TX 75390, USA. E-mail: jrutte{at}biochem.swmed.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
PAS kinase is required for normal cellular energy balance.
H.-X. Hao, C. M. Cardon, W. Swiatek, R. C. Cooksey, T. L. Smith, J. Wilde, S. Boudina, E. D. Abel, D. A. McClain, and J. Rutter (2007)
PNAS 104, 15466-15471
   Abstract »    Full Text »    PDF »
Relationships between Heme Incorporation, Tetramer Formation, and Catalysis of a Heme-regulated Phosphodiesterase from Escherichia coli: A STUDY OF DELETION AND SITE-DIRECTED MUTANTS.
T. Yoshimura, I. Sagami, Y. Sasakura, and T. Shimizu (2003)
J. Biol. Chem. 278, 53105-53111
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)