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Science 15 November 2002:
Vol. 298. no. 5597, pp. 1346 - 1347
DOI: 10.1126/science.1079168
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Perspectives

CANCER:
DNA Damage, Deamidation, and Death

Chi Li and Craig B. Thompson

DNA-damaging agents are adept at killing tumor cells by inducing them to undergo programmed cell death even though they are normally resistant to apoptosis. In their Perspective, Li and Thompson discuss new work published elsewhere that provides an explanation for this paradox. DNA damage induces deamidation of a crucial antiapoptotic protein, which overcomes the apoptotic block and allows the tumor cells to die.

The authors are in the Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA. E-mail: drt{at}mail.med.upenn.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Bcl-xl does not have to bind Bax to protect T cells from death.
X. Liu, Y. Zhu, S. Dai, J. White, F. Peyerl, J. W. Kappler, and P. Marrack (2006)
J. Exp. Med. 203, 2953-2961
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E-Letters:

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Control of protein kinase A by conserved deamidation
Volker Kinzel, et al.
Science Online, 27 Nov 2002 [Full text]

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