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Science 25 October 2002:
Vol. 298. no. 5594, pp. 761 - 763
DOI: 10.1126/science.1077707
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Perspectives

Also see the archival list of Science's Compass: Enhanced Perspectives

CANCER BIOLOGY:
Enhanced: A Matter of Dosage

Riccardo Fodde and Ron Smits

The canonical hypothesis of tumorigenesis is Knudson's two-hit model, which stipulates that both alleles of a tumor suppressor gene must be inactivated for tumors to form. In their Perspective, Fodde and Smits discuss new work revealing that this model may not hold for a subgroup of tumor suppressor genes. Inactivation of only one allele of these tumor suppressor genes is sufficient, either on its own or in combination with other deleterious events, to cause tumor formation.

The authors are at the Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, Netherlands. E-mail: r.fodde{at}lumc.nl

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