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"Stemness": Transcriptional Profiling of Embryonic and Adult Stem Cells
Miguel Ramalho-Santos,1Soonsang Yoon,2Yumi Matsuzaki,2Richard C. Mulligan,2Douglas A. Melton1*
The transcriptional profiles of mouse embryonic, neural,
and hematopoietic stem cells were compared to define a genetic programfor stem cells. A total of 216 genes are enriched in all threetypes of
stem cells, and several of these genes are clusteredin the genome.
When compared to differentiated cell types, stemcells express a
significantly higher number of genes (representedby expressed sequence
tags) whose functions are unknown. Embryonicand neural stem cells have
many similarities at the transcriptionallevel. These results provide a
foundation for a more detailedunderstanding of stem cell biology.
1 Department of Molecular and Cellular Biology
and Howard Hughes Medical Institute (HHMI), Harvard University,
Cambridge, MA 02138, USA.
2 Department of Genetics,
Harvard Medical School, Boston, MA 02115, USA.
*
To whom correspondence should be addressed. E-mail:
dmelton{at}mcb.harvard.edu
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Global transcriptional characterization of SP and MP cells from the myogenic C2C12 cell line: effect of FGF6.
C. Decraene, R. Benchaouir, M.-A. Dillies, D. Israeli, S. Bortoli, C. Rochon, P. Rameau, A. Pitaval, D. T.-L. Roux, O. Danos, et al. (2005)
Physiol Genomics
23, 132-149
|Abstract »|Full Text »|PDF »
Heat-shock protein 60 is required for blastema formation and maintenance during regeneration.
S. Makino, G. G. Whitehead, C.-L. Lien, S. Kim, P. Jhawar, A. Kono, Y. Kawata, and M. T. Keating (2005)
PNAS
102, 14599-14604
|Abstract »|Full Text »|PDF »
Diversification of stem cell molecular repertoire by alternative splicing.
M. Pritsker, T. T. Doniger, L. C. Kramer, S. E. Westcot, and I. R. Lemischka (2005)
PNAS
102, 14290-14295
|Abstract »|Full Text »|PDF »
Novel pathway for megakaryocyte production after in vivo conditional eradication of integrin {alpha}IIb-expressing cells.
B. Jacquelin, T. Kortulewski, P. Vaigot, A. Pawlik, G. Gruel, O. Alibert, P. Soularue, C. Joubert, X. Gidrol, and D. T.-L. Roux (2005)
Blood
106, 1965-1974
|Abstract »|Full Text »|PDF »
c-Myc Is Required for the Formation of Intestinal Crypts but Dispensable for Homeostasis of the Adult Intestinal Epithelium.
M. D. Bettess, N. Dubois, M. J. Murphy, C. Dubey, C. Roger, S. Robine, and A. Trumpp (2005)
Mol. Cell. Biol.
25, 7868-7878
|Abstract »|Full Text »|PDF »
Activation of Vascular Endothelial Growth Factor Receptor-2 in Bone Marrow Leads to Accumulation of Myeloid Cells: Role of Granulocyte-Macrophage Colony-Stimulating Factor.
