Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 11 October 2002:
Vol. 298. no. 5592, pp. 370 - 371
DOI: 10.1126/science.1078096
Prev | Table of Contents | Next

Perspectives

RNA EVENTS:
No End to Nonsense

Melissa J. Moore

Usually if a messenger RNA (mRNA) transcript carries an aberrant stop mutation, it is degraded before it has a chance to be translated into a truncated protein. However, sometimes a nonsense mutation can activate an alternate splicing pathway to yield a stable mRNA lacking the mutation. In a Perspective, Moore discusses new work (Mendell et al.) that identifies the first of the protein factors involved in these two separate yet overlapping pathways.

The author is in the Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, MA 02454, USA. E-mail: mmoore{at}brandeis.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Splicing in action: assessing disease causing sequence changes.
D Baralle and M Baralle (2005)
J. Med. Genet. 42, 737-748
   Abstract »    Full Text »    PDF »
ENAM Mutations in Autosomal-dominant Amelogenesis Imperfecta.
J.-W. Kim, F. Seymen, B.P.-J. Lin, B. Kiziltan, K. Gencay, J.P. Simmer, and J.C.-C. Hu (2005)
Journal of Dental Research 84, 278-282
   Abstract »    Full Text »    PDF »
MMP-20 mutation in autosomal recessive pigmented hypomaturation amelogenesis imperfecta.
J-W Kim, J P Simmer, T C Hart, P S Hart, M D Ramaswami, J D Bartlett, and J C-C Hu (2005)
J. Med. Genet. 42, 271-275
   Full Text »    PDF »
A Hox gene mutation that triggers nonsense-mediated RNA decay and affects alternative splicing during Drosophila development.
C. R. Alonso and M. Akam (2003)
Nucleic Acids Res. 31, 3873-3880
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)