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Science 11 October 2002:
Vol. 298. no. 5592, p. 319
DOI: 10.1126/science.298.5592.319e
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This Week in Science
Premature termination codons (PTCs) in messenger RNA (mRNA) result in its accelerated degradation, a process known as nonsense-mediated decay (NMD), and this process prevents the synthesis of truncated and potentially dangerous proteins. PTCs can also result in nonsense-mediated alternative splicing (NAS). Prevailing models suggest that NAS is a consequence of NMD, but Mendell et al. (p. 419; see the Perspective by Moore) now show that NMD and NAS are distinct. NMD is initiated by the assembly of a "surveillance" complex on PTC-containing mRNAs. Analysis of hUpf1 and hUpf2, protein components of this complex, show that hUpf2 only affects NMD, and that NMD and NAS are genetically separable functions of hUpf1, whose shuttling between the nucleus and cytoplasm is consistent with its role in pre-mRNA processing.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)
