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Originally published in Science Express on 5 September 2002
Science 27 September 2002:
Vol. 297. no. 5590, pp. 2256 - 2259
DOI: 10.1126/science.1074807
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Reports

Little Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells

Amy J. Wagers,* Richard I. Sherwood, Julie L. Christensen, Irving L. Weissman

To rigorously test the in vivo cell fate specificity of bone marrow (BM) hematopoietic stem cells (HSCs), we generated chimeric animals by transplantation of a single green fluorescent protein (GFP)-marked HSC into lethally irradiated nontransgenic recipients. Single HSCs robustly reconstituted peripheral blood leukocytes in these animals, but did not contribute appreciably to nonhematopoietic tissues, including brain, kidney, gut, liver, and muscle. Similarly, in GFP+:GFP- parabiotic mice, we found substantial chimerism of hematopoietic but not nonhematopoietic cells. These data indicate that "transdifferentiation" of circulating HSCs and/or their progeny is an extremely rare event, if it occurs at all.

Department of Pathology and Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
*   To whom correspondence should be addressed. E-mail: awagers{at}stanford.edu

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The nitric oxide pathway modulates hemangioblast activity of adult hematopoietic stem cells.
S. M. Guthrie, L. M. Curtis, R. N. Mames, G. G. Simon, M. B. Grant, and E. W. Scott (2005)
Blood 105, 1916-1922
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Potent Inhibitory Effect of Sirolimus on Circulating Vascular Progenitor Cells.
D. Fukuda, M. Sata, K. Tanaka, and R. Nagai (2005)
Circulation 111, 926-931
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Two distinctive pathways for recruitment of naive and primed IgM+ B cells to the gut lamina propria.
K. Suzuki, B. Meek, Y. Doi, T. Honjo, and S. Fagarasan (2005)
PNAS 102, 2482-2486
   Abstract »    Full Text »    PDF »
The biology of vascular endothelial growth factors.
T. Tammela, B. Enholm, K. Alitalo, and K. Paavonen (2005)
Cardiovasc Res 65, 550-563
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Can stem cells mend a broken heart?.
S. Davani, F. Deschaseaux, D. Chalmers, P. Tiberghien, and J.-P. Kantelip (2005)
Cardiovasc Res 65, 305-316
   Abstract »    Full Text »    PDF »
The evolving role of haematopoietic cell transplantation in radiation injury: potentials and limitations.
N Dainiak and R C Ricks (2005)
Br. J. Radiol. Supplement_27, 169-174
   Abstract »    Full Text »    PDF »
Hematopoietic stem cell transplantation does not restore dystrophin expression in Duchenne muscular dystrophy dogs.
C. Dell'Agnola, Z. Wang, R. Storb, S. J. Tapscott, C. S. Kuhr, S. D. Hauschka, R. S. Lee, G. E. Sale, E. Zellmer, S. Gisburne, et al. (2004)
Blood 104, 4311-4318
   Abstract »    Full Text »    PDF »
Cells Expressing Early Cardiac Markers Reside in the Bone Marrow and Are Mobilized Into the Peripheral Blood After Myocardial Infarction.
M. Kucia, B. Dawn, G. Hunt, Y. Guo, M. Wysoczynski, M. Majka, J. Ratajczak, F. Rezzoug, S. T. Ildstad, R. Bolli, et al. (2004)
Circ. Res. 95, 1191-1199
   Abstract »    Full Text »    PDF »


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