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Science 20 September 2002:
Vol. 297. no. 5589, p. 1953
DOI: 10.1126/science.297.5589.1953p
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This Week in Science
Both B and T lymphocyte responses require support from specialized helper T lymphocytes, which mediate their effects via the cell surface protein CD40. For B cells, this support involves direct interaction with helper T cells expressing CD40-ligand (CD40-L). For CD8+ T cells, such help has been assumed to depend on signals generated via CD40 on third-party antigen-presenting cells (APCs). Bourgeois et al. (p. 2060) developed an in vivo system for priming CD8 responses in which was present on CD8+ T cells, but absent on APCs. As expected, CD4+ cells were required to supply help via CD40-L, but could generate CD8+ T cell memory without the need for CD40 on APC. The role for CD40 on CD8+ T cells, rather than on the APC, indicates a direct form of help paralleling that used in B cell memory formation.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)
