Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Keystone Symposium

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 13 September 2002:
Vol. 297. no. 5588, pp. 1867 - 1870
DOI: 10.1126/science.1073514
Prev | Table of Contents | Next

Reports

Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase

David H. Munn,12* Madhav D. Sharma,1 Jeffrey R. Lee,13 Kanchan G. Jhaver,1dagger Theodore S. Johnson,1 Derin B. Keskin,1 Brendan Marshall,1 Phillip Chandler,1 Scott J. Antonia,4 Russell Burgess,5 Craig L. Slingluff Jr.,6 Andrew L. Mellor15

Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature CD123+ DCs. IDO+ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans.

1 Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA.
2 Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA.
3 Veterans Affairs Medical Center, and Department of Pathology, Medical College of Georgia, Augusta, GA 30912, USA.
4 Interdisciplinary Oncology Program, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
5 Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA.
6 Department of Surgery, University of Virginia, Charlottesville, VA 22908, USA.
*   To whom correspondence should be addressed. E-mail: dmunn{at}mail.mcg.edu

dagger    Current address: Lexicon Genetics, Inc., Woodlands, TX 77381, USA.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Rapid Deletional Peripheral CD8 T Cell Tolerance Induced by Allogeneic Bone Marrow: Role of Donor Class II MHC and B Cells.
T. Fehr, S. Wang, F. Haspot, J. Kurtz, P. Blaha, T. Hogan, M. Chittenden, T. Wekerle, and M. Sykes (2008)
J. Immunol. 181, 4371-4380
   Abstract »    Full Text »    PDF »
Targeting CpG Oligonucleotides to the Lymph Node by Nanoparticles Elicits Efficient Antitumoral Immunity.
C. Bourquin, D. Anz, K. Zwiorek, A.-L. Lanz, S. Fuchs, S. Weigel, C. Wurzenberger, P. von der Borch, M. Golic, S. Moder, et al. (2008)
J. Immunol. 181, 2990-2998
   Abstract »    Full Text »    PDF »
Antigen Specificity Acquisition of Adoptive CD4+ Regulatory T Cells via Acquired Peptide-MHC Class I Complexes.
S. Hao, J. Yuan, S. Xu, M. A. Munegowda, Y. Deng, J. Gordon, Z. Xing, and J. Xiang (2008)
J. Immunol. 181, 2428-2437
   Abstract »    Full Text »    PDF »
Regulatory immune cells in kidney disease.
V. W. S. Lee, Y. M. Wang, Y. P. Wang, D. Zheng, T. Polhill, Q. Cao, H. Wu, I. E. Alexander, S. I. Alexander, and D. C. H. Harris (2008)
Am J Physiol Renal Physiol 295, F335-F342
   Abstract »    Full Text »    PDF »
Antiviral NK cell responses in HIV infection: II. viral strategies for evasion and lessons for immunotherapy and vaccination.
A. Iannello, O. Debbeche, S. Samarani, and A. Ahmad (2008)
J. Leukoc. Biol. 84, 27-49
   Abstract »    Full Text »    PDF »
Deficiency of Indoleamine 2,3-Dioxygenase Enhances Commensal-Induced Antibody Responses and Protects against Citrobacter rodentium-Induced Colitis.
L. Harrington, C. V. Srikanth, R. Antony, S. J. Rhee, A. L. Mellor, H. N. Shi, and B. J. Cherayil (2008)
Infect. Immun. 76, 3045-3053
   Abstract »    Full Text »    PDF »
Dendritic Cells as Killers: Mechanistic Aspects and Potential Roles.
C. Chauvin and R. Josien (2008)
J. Immunol. 181, 11-16
   Abstract »    Full Text »    PDF »
Cancer Immunology.
O. J. Finn (2008)
N. Engl. J. Med. 358, 2704-2715
   Full Text »    PDF »
Chorionic gonadotropin induces dendritic cells to express a tolerogenic phenotype.
H. Wan, M. A. Versnel, L. M. E. Leijten, C. G. van Helden-Meeuwsen, D. Fekkes, P. J. M. Leenen, N. A. Khan, R. Benner, and R. C. M. Kiekens (2008)
J. Leukoc. Biol. 83, 894-901
   Abstract »    Full Text »    PDF »
More ADO about IDO: GVHD.
A. Curti, S. Trabanelli, and R. M. Lemoli (2008)
Blood 111, 2950
   Full Text »    PDF »
Spontaneous Renal Allograft Acceptance Associated with "Regulatory" Dendritic Cells and IDO.
C. H. Cook, A. A. Bickerstaff, J.-J. Wang, T. Nadasdy, P. Della Pelle, R. B. Colvin, and C. G. Orosz (2008)
J. Immunol. 180, 3103-3112
   Abstract »    Full Text »    PDF »
Levo- but not dextro-1-methyl tryptophan abrogates the IDO activity of human dendritic cells.
S. Lob, A. Konigsrainer, R. Schafer, H.-G. Rammensee, G. Opelz, and P. Terness (2008)
Blood 111, 2152-2154
   Abstract »    Full Text »    PDF »
Tolerogenic dendritic cells transferring hyporesponsiveness and synergizing T regulatory cells in transplant tolerance.
M. Li, X. Zhang, X. Zheng, D. Lian, Z.-X. Zhang, H. Sun, M. Suzuki, C. Vladau, X. Huang, X. Xia, et al. (2008)
Int. Immunol. 20, 285-293
   Abstract »    Full Text »    PDF »
Effect of Melanoma on Immune Function in the Regional Lymph Node Basin.
B. Negin, D. Panka, W. Wang, M. Siddiqui, N. Tawa, J. Mullen, S. Tahan, L. Mandato, A. Polivy, J. Mier, et al. (2008)
Clin. Cancer Res. 14, 654-659
   Abstract »    Full Text »    PDF »
IFN-{gamma} Arms Human Dendritic Cells to Perform Multiple Effector Functions.
L. Frasca, M. Nasso, F. Spensieri, G. Fedele, R. Palazzo, F. Malavasi, and C. M. Ausiello (2008)
J. Immunol. 180, 1471-1481
   Abstract »    Full Text »    PDF »
IFN-{gamma} Mediates the Death of Th1 Cells in a Paracrine Manner.
K. E. Foulds, M. J. Rotte, M. A. Paley, B. Singh, D. C. Douek, B. J. Hill, J. J. O'Shea, W. T. Watford, R. A. Seder, and C.-Y. Wu (2008)
J. Immunol. 180, 842-849
   Abstract »    Full Text »    PDF »
Specific recruitment of regulatory T cells into the CSF in lymphomatous and carcinomatous meningitis.
J. Haas, L. Schopp, B. Storch-Hagenlocher, B. Fritzsching, C. Jacobi, L. Milkova, B. Fritz, A. Schwarz, E. Suri-Payer, M. Hensel, et al. (2008)
Blood 111, 761-766
   Abstract »    Full Text »    PDF »
Balancing between immunity and tolerance: an interplay between dendritic cells, regulatory T cells, and effector T cells.
N. Cools, P. Ponsaerts, V. F. I. Van Tendeloo, and Z. N. Berneman (2007)
J. Leukoc. Biol. 82, 1365-1374
   Abstract »    Full Text »    PDF »
Indoleamine 2,3-dioxygenase gene transfer prolongs cardiac allograft survival.
J. Li, A. Meinhardt, M.-E. Roehrich, D. Golshayan, J. Dudler, M. Pagnotta, M. Trucco, and G. Vassalli (2007)
Am J Physiol Heart Circ Physiol 293, H3415-H3423
   Abstract »    Full Text »    PDF »
Prostaglandin E2 is a key factor for monocyte-derived dendritic cell maturation: enhanced T cell stimulatory capacity despite IDO.
P. Krause, E. Singer, P. I. Darley, J. Klebensberger, M. Groettrup, and D. F. Legler (2007)
J. Leukoc. Biol. 82, 1106-1114
   Abstract »    Full Text »    PDF »
Induction of Indoleamine 2,3-Dioxygenase in Vascular Smooth Muscle Cells by Interferon-{gamma} Contributes to Medial Immunoprivilege.
M. C. Cuffy, A. M. Silverio, L. Qin, Y. Wang, R. Eid, G. Brandacher, F. G. Lakkis, D. Fuchs, J. S. Pober, and G. Tellides (2007)
J. Immunol. 179, 5246-5254
   Abstract »    Full Text »    PDF »
Dendritic Cells in the Kidney.
R. John and P. J. Nelson (2007)
J. Am. Soc. Nephrol. 18, 2628-2635
   Abstract »    Full Text »    PDF »
Noncanonical NF-{kappa}B signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation.
S. W. Tas, M. J. Vervoordeldonk, N. Hajji, J. H. N. Schuitemaker, K. F. van der Sluijs, M. J. May, S. Ghosh, M. L. Kapsenberg, P. P. Tak, and E. C. de Jong (2007)
Blood 110, 1540-1549
   Abstract »    Full Text »    PDF »
Post-translational Regulation of Human Indoleamine 2,3-Dioxygenase Activity by Nitric Oxide.
S. R. Thomas, A. C. Terentis, H. Cai, O. Takikawa, A. Levina, P. A. Lay, M. Freewan, and R. Stocker (2007)
J. Biol. Chem. 282, 23778-23787
   Abstract »    Full Text »    PDF »
Human IL4I1 is a secreted L-phenylalanine oxidase expressed by mature dendritic cells that inhibits T-lymphocyte proliferation.
M.-L. Boulland, J. Marquet, V. Molinier-Frenkel, P. Moller, C. Guiter, F. Lasoudris, C. Copie-Bergman, M. Baia, P. Gaulard, K. Leroy, et al. (2007)
Blood 110, 220-227
   Abstract »    Full Text »    PDF »
Suppression of Memory CD8 T Cell Generation and Function by Tryptophan Catabolism.
Z. Liu, H. Dai, N. Wan, T. Wang, S. Bertera, M. Trucco, and Z. Dai (2007)
J. Immunol. 178, 4260-4266
   Abstract »    Full Text »    PDF »
Modulation of tryptophan catabolism by human leukemic cells results in the conversion of CD25- into CD25+ T regulatory cells.
A. Curti, S. Pandolfi, B. Valzasina, M. Aluigi, A. Isidori, E. Ferri, V. Salvestrini, G. Bonanno, S. Rutella, I. Durelli, et al. (2007)
Blood 109, 2871-2877
   Abstract »    Full Text »    PDF »
Inhibition of Indoleamine 2,3-Dioxygenase in Dendritic Cells by Stereoisomers of 1-Methyl-Tryptophan Correlates with Antitumor Responses.
D.-Y. Hou, A. J. Muller, M. D. Sharma, J. DuHadaway, T. Banerjee, M. Johnson, A. L. Mellor, G. C. Prendergast, and D. H. Munn (2007)
Cancer Res. 67, 792-801
   Abstract »    Full Text »    PDF »
A putative mechanism on remission of multiple sclerosis during pregnancy: estrogen-induced indoleamine 2,3-dioxygenase by dendritic cells.
W-H Zhu, C-Z Lu, Y-M Huang, H Link, and B-G Xiao (2007)
Multiple Sclerosis 13, 33-40
   Abstract »    PDF »
The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function.
M. D. Chiesa, S. Carlomagno, G. Frumento, M. Balsamo, C. Cantoni, R. Conte, L. Moretta, A. Moretta, and M. Vitale (2006)
Blood 108, 4118-4125
   Abstract »    Full Text »    PDF »
IRF-1 deficiency skews the differentiation of dendritic cells toward plasmacytoid and tolerogenic features.
L. Gabriele, A. Fragale, P. Borghi, P. Sestili, E. Stellacci, M. Venditti, G. Schiavoni, M. Sanchez, F. Belardelli, and A. Battistini (2006)
J. Leukoc. Biol. 80, 1500-1511
   Abstract »    Full Text »    PDF »
A high-affinity, tryptophan-selective amino acid transport system in human macrophages.
R. L. Seymour, V. Ganapathy, A. L. Mellor, and D. H. Munn (2006)
J. Leukoc. Biol. 80, 1320-1327
   Abstract »    Full Text »    PDF »
Synovial Autoreactive T Cells in Rheumatoid Arthritis Resist IDO-Mediated Inhibition.
L. Zhu, F. Ji, Y. Wang, Y. Zhang, Q. Liu, J. Z. Zhang, K. Matsushima, Q. Cao, and Y. Zhang (2006)
J. Immunol. 177, 8226-8233
   Abstract »    Full Text »    PDF »
Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung.
M. E. Rothenberg, M. P. Doepker, I. P. Lewkowich, M. G. Chiaramonte, K. F. Stringer, F. D. Finkelman, C. L. MacLeod, L. G. Ellies, and N. Zimmermann (2006)
PNAS 103, 14895-14900
   Abstract »    Full Text »    PDF »
Thymosin {alpha}1 activates dendritic cell tryptophan catabolism and establishes a regulatory environment for balance of inflammation and tolerance.
L. Romani, F. Bistoni, K. Perruccio, C. Montagnoli, R. Gaziano, S. Bozza, P. Bonifazi, G. Bistoni, G. Rasi, A. Velardi, et al. (2006)
Blood 108, 2265-2274
   Abstract »    Full Text »    PDF »
Adult stem cells in the treatment of autoimmune diseases.
J. M. van Laar and A. Tyndall (2006)
Rheumatology 45, 1187-1193
   Abstract »    Full Text »    PDF »
Tolerogenic dendritic cells: cytokine modulation comes of age.
S. Rutella, S. Danese, and G. Leone (2006)
Blood 108, 1435-1440
   Abstract »    Full Text »    PDF »
1-Methyl-Tryptophan Can Interfere with TLR Signaling in Dendritic Cells Independently of IDO Activity.
S. Agaugue, L. Perrin-Cocon, F. Coutant, P. Andre, and V. Lotteau (2006)
J. Immunol. 177, 2061-2071
   Abstract »    Full Text »    PDF »
Endothelial stroma programs hematopoietic stem cells to differentiate into regulatory dendritic cells through IL-10.
H. Tang, Z. Guo, M. Zhang, J. Wang, G. Chen, and X. Cao (2006)
Blood 108, 1189-1197
   Abstract »    Full Text »    PDF »
CTLA-4 Overexpression Inhibits T Cell Responses through a CD28-B7-Dependent Mechanism.
J. J. Engelhardt, T. J. Sullivan, and J. P. Allison (2006)
J. Immunol. 177, 1052-1061
   Abstract »    Full Text »    PDF »
Hepatocyte growth factor favors monocyte differentiation into regulatory interleukin (IL)-10++IL-12low/neg accessory cells with dendritic-cell features.
S. Rutella, G. Bonanno, A. Procoli, A. Mariotti, D. G. de Ritis, A. Curti, S. Danese, G. Pessina, S. Pandolfi, F. Natoni, et al. (2006)
Blood 108, 218-227
   Abstract »    Full Text »    PDF »
CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition.
M. S. von Bergwelt-Baildon, A. Popov, T. Saric, J. Chemnitz, S. Classen, M. S. Stoffel, F. Fiore, U. Roth, M. Beyer, S. Debey, et al. (2006)
Blood 108, 228-237
   Abstract »    Full Text »    PDF »
Tumor-Driven Evolution of Immunosuppressive Networks during Malignant Progression.
R. Kim, M. Emi, K. Tanabe, and K. Arihiro (2006)
Cancer Res. 66, 5527-5536
   Abstract »    Full Text »    PDF »
The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor {zeta}-Chain and Induce a Regulatory Phenotype in Naive T Cells..
F. Fallarino, U. Grohmann, S. You, B. C. McGrath, D. R. Cavener, C. Vacca, C. Orabona, R. Bianchi, M. L. Belladonna, C. Volpi, et al. (2006)
J. Immunol. 176, 6752-6761
   Abstract »    Full Text »    PDF »
Combinational FLt3 Ligand and Granulocyte Macrophage Colony-Stimulating Factor Treatment Promotes Enhanced Tumor Infiltration by Dendritic Cells and Antitumor CD8+ T-Cell Cross-priming but Is Ineffective as a Therapy..
A. Berhanu, J. Huang, S. M. Alber, S. C. Watkins, and W. J. Storkus (2006)
Cancer Res. 66, 4895-4903
   Abstract »    Full Text »    PDF »
Prognostic Value of Indoleamine 2,3-Dioxygenase Expression in Colorectal Cancer: Effect on Tumor-Infiltrating T Cells.
G. Brandacher, A. Perathoner, R. Ladurner, S. Schneeberger, P. Obrist, C. Winkler, E. R. Werner, G. Werner-Felmayer, H. G. Weiss, G. Gobel, et al. (2006)
Clin. Cancer Res. 12, 1144-1151
   Abstract »    Full Text »    PDF »
Immunity and Tolerance to Aspergillus Involve Functionally Distinct Regulatory T Cells and Tryptophan Catabolism.
C. Montagnoli, F. Fallarino, R. Gaziano, S. Bozza, S. Bellocchio, T. Zelante, W. P. Kurup, L. Pitzurra, P. Puccetti, and L. Romani (2006)
J. Immunol. 176, 1712-1723
   Abstract »    Full Text »    PDF »
Role for Interferon-{gamma} in the Immunomodulatory Activity of Human Bone Marrow Mesenchymal Stem Cells.
M. Krampera, L. Cosmi, R. Angeli, A. Pasini, F. Liotta, A. Andreini, V. Santarlasci, B. Mazzinghi, G. Pizzolo, F. Vinante, et al. (2006)
Stem Cells 24, 386-398
   Abstract »    Full Text »    PDF »
Interleukin-7 Is a Survival Factor for CD4+ CD25+ T-Cells and Is Expressed by Diabetes-Suppressive Dendritic Cells.
J. Harnaha, J. Machen, M. Wright, R. Lakomy, A. Styche, M. Trucco, S. Makaroun, and N. Giannoukakis (2006)
Diabetes 55, 158-170
   Abstract »    Full Text »    PDF »
IDO expression on decidual and peripheral blood dendritic cells and monocytes/macrophages after treatment with CTLA-4 or interferon-{gamma} increase in normal pregnancy but decrease in spontaneous abortion.
N. Miwa, S. Hayakawa, S. Miyazaki, S. Myojo, Y. Sasaki, M. Sakai, O. Takikawa, and S. Saito (2005)
Mol. Hum. Reprod. 11, 865-870
   Abstract »    Full Text »    PDF »
Ligand and cytokine dependence of the immunosuppressive pathway of tryptophan catabolism in plasmacytoid dendritic cells.
F. Fallarino, C. Orabona, C. Vacca, R. Bianchi, S. Gizzi, C. Asselin-Paturel, M. C. Fioretti, G. Trinchieri, U. Grohmann, and P. Puccetti (2005)
Int. Immunol. 17, 1429-1438
   Abstract »    Full Text »    PDF »
Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression.
P. H. Tan, J. B. Yates, S.-A. Xue, C. Chan, W. J. Jordan, J. E. Harper, M. P. Watson, R. Dong, M. A. Ritter, R. I. Lechler, et al. (2005)
Blood 106, 2936-2943
   Abstract »    Full Text »    PDF »
A two-step induction of indoleamine 2,3 dioxygenase (IDO) activity during dendritic-cell maturation.
D. Braun, R. S. Longman, and M. L. Albert (2005)
Blood 106, 2375-2381
   Abstract »    Full Text »    PDF »
Distinct and Overlapping Roles of Interleukin-10 and CD25+ Regulatory T Cells in the Inhibition of Antitumor CD8 T-Cell Responses.
C. Dercamp, K. Chemin, C. Caux, G. Trinchieri, and A. P. Vicari (2005)
Cancer Res. 65, 8479-8486
   Abstract »    Full Text »    PDF »
Early Cytokine Production Is Associated with Protection from Murine Cerebral Malaria.
A. J. Mitchell, A. M. Hansen, L. Hee, H. J. Ball, S. M. Potter, J. C. Walker, and N. H. Hunt (2005)
Infect. Immun. 73, 5645-5653
   Abstract »    Full Text »    PDF »
Profiling dendritic cell maturation with dedicated microarrays.
D. McIlroy, S. Tanguy-Royer, N. Le Meur, I. Guisle, P.-J. Royer, J. Leger, K. Meflah, and M. Gregoire (2005)
J. Leukoc. Biol. 78, 794-803
   Abstract »    Full Text »    PDF »
Indoleamine 2,3-Dioxygenase Serves as a Marker of Poor Prognosis in Gene Expression Profiles of Serous Ovarian Cancer Cells.
A. Okamoto, T. Nikaido, K. Ochiai, S. Takakura, M. Saito, Y. Aoki, N. Ishii, N. Yanaihara, K. Yamada, O. Takikawa, et al. (2005)
Clin. Cancer Res. 11, 6030-6039
   Abstract »    Full Text »    PDF »
Immunoregulation of Dendritic Cells.
M. A Wallet, P. Sen, and R. Tisch (2005)
Clin. Med. Res. 3, 166-175
   Abstract »    Full Text »    PDF »
Human Dendritic Cells: Potent Antigen-Presenting Cells at the Crossroads of Innate and Adaptive Immunity.
M. Rossi and J. W. Young (2005)
J. Immunol. 175, 1373-1381
   Abstract »    Full Text »    PDF »
Blockade of B7-H1 on Macrophages Suppresses CD4+ T Cell Proliferation by Augmenting IFN-{gamma}-Induced Nitric Oxide Production.
T. Yamazaki, H. Akiba, A. Koyanagi, M. Azuma, H. Yagita, and K. Okumura (2005)
J. Immunol. 175, 1586-1592
   Abstract »    Full Text »    PDF »
A minor population of splenic dendritic cells expressing CD19 mediates IDO-dependent T cell suppression via type I IFN signaling following B7 ligation.
B. Baban, A. M. Hansen, P. R. Chandler, A. Manlapat, A. Bingaman, D. J. Kahler, D. H. Munn, and A. L. Mellor (2005)
Int. Immunol. 17, 909-919
   Abstract »    Full Text »    PDF »
A cautionary tale.
D. H. Munn (2005)
Blood 105, 3761-3762
   Full Text »    PDF »
Monocyte-mediated T-cell suppression and augmented monocyte tryptophan catabolism after human hematopoietic stem-cell transplantation.
U. Hainz, P. Obexer, C. Winkler, P. Sedlmayr, O. Takikawa, H. Greinix, A. Lawitschka, U. Putschger, D. Fuchs, S. Ladisch, et al. (2005)
Blood 105, 4127-4134
   Abstract »    Full Text »    PDF »
Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells.
S. Glennie, I. Soeiro, P. J. Dyson, E. W.-F. Lam, and F. Dazzi (2005)
Blood 105, 2821-2827
   Abstract »    Full Text »    PDF »
CCR6 expression defines regulatory effector/memory-like cells within the CD25+CD4+ T-cell subset.
M. Kleinewietfeld, F. Puentes, G. Borsellino, L. Battistini, O. Rotzschke, and K. Falk (2005)
Blood 105, 2877-2886
   Abstract »    Full Text »    PDF »
Dendritic cells have the option to express IDO-mediated suppression or not.
D. H. Munn, A. L. Mellor, M. Rossi, and J. W. Young (2005)
Blood 105, 2618
   Full Text »    PDF »
Regulation of human auto- and alloreactive T cells by indoleamine 2,3-dioxygenase (IDO)-producing dendritic cells: too much ado about IDO?.
P. Terness, J.-J. Chuang, T. Bauer, L. Jiga, and G. Opelz (2005)
Blood 105, 2480-2486
   Abstract »    Full Text »    PDF »
A Crucial Role for Tryptophan Catabolism at the Host/Candida albicans Interface.
S. Bozza, F. Fallarino, L. Pitzurra, T. Zelante, C. Montagnoli, S. Bellocchio, P. Mosci, C. Vacca, P. Puccetti, and L. Romani (2005)
J. Immunol. 174, 2910-2918
   Abstract »    Full Text »    PDF »
Intercellular Adhesion Molecule-1/LFA-1 Cross Talk Is a Proximate Mediator Capable of Disrupting Immune Integration and Tolerance Mechanism at the Feto-Maternal Interface in Murine Pregnancies.
S. Blois, M. Tometten, J. Kandil, E. Hagen, B. F. Klapp, R. A. Margni, and P. C. Arck (2005)
J. Immunol. 174, 1820-1829
   Abstract »    Full Text »    PDF »
Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells.
A. Boasso, J.-P. Herbeuval, A. W. Hardy, C. Winkler, and G. M. Shearer (2005)
Blood 105, 1574-1581
   Abstract »    Full Text »    PDF »
Quantitative Analysis of Melanoma-Induced Cytokine-Mediated Immunosuppression in Melanoma Sentinel Nodes.
J. H. Lee, H. Torisu-Itakara, A. J. Cochran, A. Kadison, Y. Huynh, D. L. Morton, and R. Essner (2005)
Clin. Cancer Res. 11, 107-112
   Abstract »    Full Text »    PDF »
Fas Ligand as a Tool for Immunosuppression and Generation of Immune Tolerance.
O. Bohana-Kashtan and C. I. Civin (2004)
Stem Cells 22, 908-924
   Abstract »    Full Text »    PDF »
Mechanisms regulating the expression of indoleamine 2,3-dioxygenase during decidualization of human endometrium.
A. Honig, L. Rieger, J. Dietl, and U. Kammerer (2004)
Hum. Reprod. 19, 2683-2684
   Full Text »    PDF »
Manipulating dendritic cell biology for the active immunotherapy of cancer.
D. W. O'Neill, S. Adams, and N. Bhardwaj (2004)
Blood 104, 2235-2246
   Abstract »    Full Text »    PDF »
Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase.
A. L. Mellor, P. Chandler, B. Baban, A. M. Hansen, B. Marshall, J. Pihkala, H. Waldmann, S. Cobbold, E. Adams, and D. H. Munn (2004)
Int. Immunol. 16, 1391-1401
   Abstract »    Full Text »    PDF »
In Reply:.
C. L. Slingluff Jr (2004)
J. Clin. Oncol. 22, 3835
   Full Text »    PDF »
Murine Plasmacytoid Dendritic Cells Initiate the Immunosuppressive Pathway of Tryptophan Catabolism in Response to CD200 Receptor Engagement.
F. Fallarino, C. Asselin-Paturel, C. Vacca, R. Bianchi, S. Gizzi, M. C. Fioretti, G. Trinchieri, U. Grohmann, and P. Puccetti (2004)
J. Immunol. 173, 3748-3754
   Abstract »    Full Text »    PDF »