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Science 6 September 2002:
Vol. 297. no. 5587, pp. 1626 - 1627
DOI: 10.1126/science.297.5587.1626b
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News of the Week

INFLAMMATORY ARTHRITIS:
How Immune System Gangs Up on Joints

Mary Beckman

Mast cells are best known for releasing the allergy compound histamine, which induces sniffles and swollen eyes. Now rheumatologists have found the cells embroiled in inflammatory arthritis. On page 1689, a team reports that mast cells in mice act as a bridge linking arthritis's self-attacking antibodies and the inflammation that swells joints.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)