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Science 23 August 2002:
Vol. 297. no. 5585, pp. 1260 - 1262
DOI: 10.1126/science.297.5585.1260
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News Focus

NEW THERAPIES:
New Alzheimer's Treatments That May Ease the Mind

Laura Helmuth

STOCKHOLM--Alzheimer's researchers gathered here last month with a sense of urgency and optimism about possible treatments--and perhaps preventions--for the mind-robbing disease. The 4000 attendees heard about progress on several fronts, including possible vaccines and treatments aimed at either blocking formation of b amyloid, a small peptide thought to trigger the loss of brain neurons, or at dissolving the abnormal b-amyloid deposits that are a hallmark of the disease. This special focus also explores a debate over which drugs to test in a prevention trial.

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Therapeutic targets: progress of their exploration and investigation of their characteristics..
C. J. Zheng, L. Y. Han, C. W. Yap, Z. L. Ji, Z. W. Cao, and Y. Z. Chen (2006)
Pharmacol. Rev. 58, 259-279
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Prototype Alzheimer's Disease Vaccine Using the Immunodominant B Cell Epitope from {beta}-Amyloid and Promiscuous T Cell Epitope Pan HLA DR-Binding Peptide.
M. G. Agadjanyan, A. Ghochikyan, I. Petrushina, V. Vasilevko, N. Movsesyan, M. Mkrtichyan, T. Saing, and D. H. Cribbs (2005)
J. Immunol. 174, 1580-1586
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Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with {beta}-amyloid.
D. H. Cribbs, A. Ghochikyan, V. Vasilevko, M. Tran, I. Petrushina, N. Sadzikava, D. Babikyan, P. Kesslak, T. Kieber-Emmons, C. W. Cotman, et al. (2003)
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Science. ISSN 0036-8075 (print), 1095-9203 (online)