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Science 9 August 2002:
Vol. 297. no. 5583, p. 893
DOI: 10.1126/science.297.5583.893o
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Infectious poliovirus has been assembled through a process in which the genome sequence served only as the blueprint. Cello et al. (p. 1016) used a combination of organic synthesis, recombinant DNA methods, and an established system of replication in a cell-free system to produce a virus that is neurovirulent in mice. If viruses no longer found in nature can be reconstituted from organic precursors, then this demonstration has important implications concerning the eradication of poliovirus.




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