Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 12 July 2002:
Vol. 297. no. 5579, pp. 240 - 243
DOI: 10.1126/science.1071527
Prev | Table of Contents | Next

Reports

Role for Stearoyl-CoA Desaturase-1 in Leptin-Mediated Weight Loss

Paul Cohen,1 Makoto Miyazaki,5 Nicholas D. Socci,12 Aaron Hagge-Greenberg,1 Wolfgang Liedtke,1 Alexander A. Soukas,1 Ratnendra Sharma,1 Lisa C. Hudgins,3 James M. Ntambi,56 Jeffrey M. Friedman14*

Leptin elicits a metabolic response that cannot be explained by its anorectic effects alone. To examine the mechanism underlying leptin's metabolic actions, we used transcription profiling to identify leptin-regulated genes in ob/ob liver. Leptin was found to specifically repress RNA levels and enzymatic activity of hepatic stearoyl-CoA desaturase-1 (SCD-1), which catalyzes the biosynthesis of monounsaturated fatty acids. Mice lacking SCD-1 were lean and hypermetabolic. ob/ob mice with mutations in SCD-1 were significantly less obese than ob/ob controls and had markedly increased energy expenditure. ob/ob mice with mutations in SCD-1 had histologically normal livers with significantly reduced triglyceride storage and VLDL (very low density lipoprotein) production. These findings suggest that down-regulation of SCD-1 is an important component of leptin's metabolic actions.

1 Laboratory of Molecular Genetics,
2 Center for Studies in Physics and Biology,
3 Rogosin Institute,
4 Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
5 Department of Biochemistry and
6 Department of Nutritional Sciences, University of Wisconsin, Madison, WI 53706, USA.
*   To whom correspondence should be addressed. E-mail: friedj{at}rockvax.rockefeller.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
AMPK in Health and Disease.
G. R. Steinberg and B. E. Kemp (2009)
Physiol Rev 89, 1025-1078
   Abstract »    Full Text »    PDF »
Hypocaloric high-protein diet improves fatty liver and hypertriglyceridemia in sucrose-fed obese rats via two pathways.
T. Uebanso, Y. Taketani, M. Fukaya, K. Sato, Y. Takei, T. Sato, N. Sawada, K. Amo, N. Harada, H. Arai, et al. (2009)
Am J Physiol Endocrinol Metab 297, E76-E84
   Abstract »    Full Text »    PDF »
Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet.
K. A. Posey, D. J. Clegg, R. L. Printz, J. Byun, G. J. Morton, A. Vivekanandan-Giri, S. Pennathur, D. G. Baskin, J. W. Heinecke, S. C. Woods, et al. (2009)
Am J Physiol Endocrinol Metab 296, E1003-E1012
   Abstract »    Full Text »    PDF »
Despite Antiatherogenic Metabolic Characteristics, SCD1-Deficient Mice Have Increased Inflammation and Atherosclerosis.
M. L.E. MacDonald, M. van Eck, R. B. Hildebrand, B. W.C. Wong, N. Bissada, P. Ruddle, A. Kontush, H. Hussein, M. A. Pouladi, M. J. Chapman, et al. (2009)
Arterioscler. Thromb. Vasc. Biol. 29, 341-347
   Abstract »    Full Text »    PDF »
Central Leptin Regulates Total Ceramide Content and Sterol Regulatory Element Binding Protein-1C Proteolytic Maturation in Rat White Adipose Tissue.
E. Bonzon-Kulichenko, D. Schwudke, N. Gallardo, E. Molto, T. Fernandez-Agullo, A. Shevchenko, and A. Andres (2009)
Endocrinology 150, 169-178
   Abstract »    Full Text »    PDF »
Hepatic Stearoyl-CoA Desaturase (SCD)-1 Activity and Diacylglycerol but Not Ceramide Concentrations Are Increased in the Nonalcoholic Human Fatty Liver.
A. Kotronen, T. Seppanen-Laakso, J. Westerbacka, T. Kiviluoto, J. Arola, A.-L. Ruskeepaa, M. Oresic, and H. Yki-Jarvinen (2009)
Diabetes 58, 203-208
   Abstract »    Full Text »    PDF »
Cloning and Expression of Delta-Like Protein 1 Messenger Ribonucleic Acid During Development of Adipose and Muscle Tissues in Chickens.
J. Shin, S. Lim, J. D. Latshaw, and K. Lee (2008)
Poult. Sci. 87, 2636-2646
   Abstract »    Full Text »    PDF »
Fibroblast Growth Factor 21 Corrects Obesity in Mice.
T. Coskun, H. A. Bina, M. A. Schneider, J. D. Dunbar, C. C. Hu, Y. Chen, D. E. Moller, and A. Kharitonenkov (2008)
Endocrinology 149, 6018-6027
   Abstract »    Full Text »    PDF »
Endocannabinoids and the Control of Energy Homeostasis.
G. Kunos, D. Osei-Hyiaman, J. Liu, G. Godlewski, and S. Batkai (2008)
J. Biol. Chem. 283, 33021-33025
   Abstract »    Full Text »    PDF »
Dyslipidemia and Atherosclerosis Induced by Chronic Intermittent Hypoxia Are Attenuated by Deficiency of Stearoyl Coenzyme A Desaturase.
V. Savransky, J. Jun, J. Li, A. Nanayakkara, S. Fonti, A. B. Moser, K. E. Steele, M. A. Schweitzer, S. P. Patil, S. Bhanot, et al. (2008)
Circ. Res. 103, 1173-1180
   Abstract »    Full Text »    PDF »
Thematic Review Series: Glycerolipids. DGAT enzymes and triacylglycerol biosynthesis.
C.-L. E. Yen, S. J. Stone, S. Koliwad, C. Harris, and R. V. Farese Jr. (2008)
J. Lipid Res. 49, 2283-2301
   Abstract »    Full Text »    PDF »
Stearoyl-Coenzyme A Desaturase 1 Gene Expression Increases after Pioglitazone Treatment and Is Associated with Peroxisomal Proliferator-Activated Receptor-{gamma} Responsiveness.
A. Yao-Borengasser, N. Rassouli, V. Varma, A. M. Bodles, N. Rasouli, R. Unal, B. Phanavanh, G. Ranganathan, R. E. McGehee Jr., and P. A. Kern (2008)
J. Clin. Endocrinol. Metab. 93, 4431-4439
   Abstract »    Full Text »    PDF »
Leptin Regulates Peripheral Lipid Metabolism Primarily through Central Effects on Food Intake.
X. Prieur, Y. C. L. Tung, J. L. Griffin, I. S. Farooqi, S. O'Rahilly, and A. P. Coll (2008)
Endocrinology 149, 5432-5439
   Abstract »    Full Text »    PDF »
Amylin-Mediated Restoration of Leptin Responsiveness in Diet-Induced Obesity: Magnitude and Mechanisms.
J. L. Trevaskis, T. Coffey, R. Cole, C. Lei, C. Wittmer, B. Walsh, C. Weyer, J. Koda, A. D. Baron, D. G. Parkes, et al. (2008)
Endocrinology 149, 5679-5687
   Abstract »    Full Text »    PDF »
Loss of Ncb5or Results in Impaired Fatty Acid Desaturation, Lipoatrophy, and Diabetes.
K. Larade, Z. Jiang, Y. Zhang, W. Wang, S. Bonner-Weir, H. Zhu, and H. F. Bunn (2008)
J. Biol. Chem. 283, 29285-29291
   Abstract »    Full Text »    PDF »
Inhibition of Stearoyl-Coenzyme A Desaturase 1 Dissociates Insulin Resistance and Obesity From Atherosclerosis.
J. M. Brown, S. Chung, J. K. Sawyer, C. Degirolamo, H. M. Alger, T. Nguyen, X. Zhu, M.-N. Duong, A. L. Wibley, R. Shah, et al. (2008)
Circulation 118, 1467-1475
   Abstract »    Full Text »    PDF »
Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity.
A. Peter, C. Weigert, H. Staiger, K. Rittig, A. Cegan, P. Lutz, F. Machicao, H.-U. Haring, and E. Schleicher (2008)
Am J Physiol Endocrinol Metab 295, E339-E349
   Abstract »    Full Text »    PDF »
Inhibition of stearoyl CoA desaturase activity induces hypercholesterolemia in the cholesterol-fed hamster.
C. A. Major, K. Ryan, A. J. Bennett, A. L. Lock, D. E. Bauman, and A. M. Salter (2008)
J. Lipid Res. 49, 1456-1465
   Abstract »    Full Text »    PDF »
Regulation of energy substrate utilization and hepatic insulin sensitivity by phosphatidylcholine transfer protein/StarD2.
E. F. Scapa, A. Pocai, M. K. Wu, R. Gutierrez-Juarez, L. Glenz, K. Kanno, H. Li, S. Biddinger, L. A. Jelicks, L. Rossetti, et al. (2008)
FASEB J 22, 2579-2590
   Abstract »    Full Text »    PDF »
Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1.
A.-H. Lee, E. F. Scapa, D. E. Cohen, and L. H. Glimcher (2008)
Science 320, 1492-1496
   Abstract »    Full Text »    PDF »
Adipokines and the Peripheral and Neural Control of Energy Balance.
R. S. Ahima and M. A. Lazar (2008)
Mol. Endocrinol. 22, 1023-1031
   Abstract »    Full Text »    PDF »
Selective Loss of Leptin Receptors in the Ventromedial Hypothalamic Nucleus Results in Increased Adiposity and a Metabolic Syndrome.
N. C. Bingham, K. K. Anderson, A. L. Reuter, N. R. Stallings, and K. L. Parker (2008)
Endocrinology 149, 2138-2148
   Abstract »    Full Text »    PDF »
Hyperleptinemia without Obesity in Male Mice Lacking Androgen Receptor in Adipose Tissue.
I-C. Yu, H.-Y. Lin, N.-C. Liu, R.-S. Wang, J. D. Sparks, S. Yeh, and C. Chang (2008)
Endocrinology 149, 2361-2368
   Abstract »    Full Text »    PDF »
Thrifty metabolism that favors fat storage after caloric restriction: a role for skeletal muscle phosphatidylinositol-3-kinase activity and AMP-activated protein kinase.
S. Summermatter, D. Mainieri, A. P. Russell, J. Seydoux, J. P. Montani, A. Buchala, G. Solinas, and A. G. Dulloo (2008)
FASEB J 22, 774-785
   Abstract »    Full Text »    PDF »
Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart.
P. Dobrzyn, H. Sampath, A. Dobrzyn, M. Miyazaki, and J. M. Ntambi (2008)
Am J Physiol Endocrinol Metab 294, E357-E364
   Abstract »    Full Text »    PDF »
Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice.
M. L. E. MacDonald, R. R. Singaraja, N. Bissada, P. Ruddle, R. Watts, J. M. Karasinska, W. T. Gibson, C. Fievet, J. E. Vance, B. Staels, et al. (2008)
J. Lipid Res. 49, 217-229
   Abstract »    Full Text »    PDF »
Leptin: A Central Role in an Expanding Answer to Weight Loss.
M. J. Holness (2007)
Endocrinology 148, 5601-5603
   Full Text »    PDF »
Evidence for a quantitative trait locus affecting low levels of apolipoprotein B and low density lipoprotein on chromosome 10 in Caucasian families.
R. Sherva, P. Yue, G. Schonfeld, and R. J. Neuman (2007)
J. Lipid Res. 48, 2632-2639
   Abstract »    Full Text »    PDF »
Tissue-Specific Effects of Central Leptin on the Expression of Genes Involved in Lipid Metabolism in Liver and White Adipose Tissue.
N. Gallardo, E. Bonzon-Kulichenko, T. Fernandez-Agullo, E. Molto, S. Gomez-Alonso, P. Blanco, J. M. Carrascosa, M. Ros, and A. Andres (2007)
Endocrinology 148, 5604-5610
   Abstract »    Full Text »    PDF »
Benefits of lifestyle modification in NAFLD.
S. A Harrison and C. P. Day (2007)
Gut 56, 1760-1769
   Full Text »    PDF »
Effect of age and moderate food restriction on insulin sensitivity in Wistar rats: role of adiposity.
F. Escriva, M L. Gavete, Y. Fermin, C. Perez, N. Gallardo, C. Alvarez, A. Andres, M. Ros, and J. M Carrascosa (2007)
J. Endocrinol. 194, 131-141
   Abstract »    Full Text »    PDF »
Short Communication: Effect of Stearoyl-Coenzyme A Desaturase Polymorphism on Fatty Acid Composition of Milk.
B. Moioli, G. Contarini, A. Avalli, G. Catillo, L. Orru, G. De Matteis, G. Masoero, and F. Napolitano (2007)
J Dairy Sci 90, 3553-3558
   Abstract »    Full Text »    PDF »
Chronic Intermittent Hypoxia Induces Atherosclerosis.
V. Savransky, A. Nanayakkara, J. Li, S. Bevans, P. L. Smith, A. Rodriguez, and V. Y. Polotsky (2007)
Am. J. Respir. Crit. Care Med. 175, 1290-1297
   Abstract »    Full Text »    PDF »
Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification.
M. Westerterp, J. F. P. Berbee, D. J. M. Delsing, M. C. Jong, M. J. J. Gijbels, V. E. H. Dahlmans, E. H. Offerman, J. A. Romijn, L. M. Havekes, and P. C. N. Rensen (2007)
J. Lipid Res. 48, 1353-1361
   Abstract »    Full Text »    PDF »
Combined effects of rosiglitazone and conjugated linoleic acid on adiposity, insulin sensitivity, and hepatic steatosis in high-fat-fed mice.
L.-F. Liu, A. Purushotham, A. A. Wendel, and M. A. Belury (2007)
Am J Physiol Gastrointest Liver Physiol 292, G1671-G1682
   Abstract »    Full Text »    PDF »
Fatty Acid Desaturation and the Regulation of Adiposity in Caenorhabditis elegans.
T. J. Brock, J. Browse, and J. L. Watts (2007)
Genetics 176, 865-875
   Abstract »    Full Text »    PDF »
Laminar shear stress up-regulates the expression of stearoyl-CoA desaturase-1 in vascular endothelial cells.
X. Qin, J. Tian, P. Zhang, Y. Fan, L. Chen, Y. Guan, Y. Fu, Y. Zhu, S. Chien, and N. Wang (2007)
Cardiovasc Res 74, 506-514
   Abstract »    Full Text »    PDF »
Interpreting physiological responses to environmental change through gene expression profiling.
A. Y. Gracey (2007)
J. Exp. Biol. 210, 1584-1592
   Abstract »    Full Text »    PDF »
Loss of Stearoyl-CoA Desaturase-1 Improves Insulin Sensitivity in Lean Mice but Worsens Diabetes in Leptin-Deficient Obese Mice.
J. B. Flowers, M. E. Rabaglia, K. L. Schueler, M. T. Flowers, H. Lan, M. P. Keller, J. M. Ntambi, and A. D. Attie (2007)
Diabetes 56, 1228-1239
   Abstract »    Full Text »    PDF »
Hyperlipidemia and lipid peroxidation are dependent on the severity of chronic intermittent hypoxia.
J. Li, V. Savransky, A. Nanayakkara, P. L. Smith, C. P. O'Donnell, and V. Y. Polotsky (2007)
J Appl Physiol 102, 557-563
   Abstract »    Full Text »    PDF »
Stearoyl-CoA Desaturase-1 Mediates the Pro-lipogenic Effects of Dietary Saturated Fat.
H. Sampath, M. Miyazaki, A. Dobrzyn, and J. M. Ntambi (2007)
J. Biol. Chem. 282, 2483-2493
   Abstract »    Full Text »    PDF »
The regulation of stearoyl-CoA desaturase gene expression is tissue specific in chickens.
S. Dridi, M. Taouis, A. Gertler, E. Decuypere, and J. Buyse (2007)
J. Endocrinol. 192, 229-236
   Abstract »    Full Text »    PDF »
Gene expression profiling of bovine skeletal muscle in response to and during recovery from chronic and severe undernutrition.
S. A. Lehnert, K. A. Byrne, A. Reverter, G. S. Nattrass, P. L. Greenwood, Y. H. Wang, N. J. Hudson, and G. S. Harper (2006)
J Anim Sci 84, 3239-3250
   Abstract »    Full Text »    PDF »
Brain Adipocytokine Action and Metabolic Regulation.
R. S. Ahima, Y. Qi, N. S. Singhal, M. B. Jackson, and P. E. Scherer (2006)
Diabetes 55, S145-S154
   Abstract »    Full Text »    PDF »
Serum cholesteryl fatty acid composition and plasma glucose concentrations in Amerindian women..
F. Lindgarde, B. Vessby, and B. Ahren (2006)
Am. J. Clinical Nutrition 84, 1009-1013
   Abstract »    Full Text »    PDF »
Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1.
G. Rizki, L. Arnaboldi, B. Gabrielli, J. Yan, G. S. Lee, R. K. Ng, S. M. Turner, T. M. Badger, R. E. Pitas, and J. J. Maher (2006)
J. Lipid Res. 47, 2280-2290
   Abstract »    Full Text »    PDF »
Stearoyl-Coenzyme A Desaturase 1 Deficiency Protects against Hypertriglyceridemia and Increases Plasma High-Density Lipoprotein Cholesterol Induced by Liver X Receptor Activation..
K. Chu, M. Miyazaki, W. C. Man, and J. M. Ntambi (2006)
Mol. Cell. Biol. 26, 6786-6798
   Abstract »    Full Text »    PDF »
Colocalization of SCD1 and DGAT2: implying preference for endogenous monounsaturated fatty acids in triglyceride synthesis.
W. C. Man, M. Miyazaki, K. Chu, and J. Ntambi (2006)
J. Lipid Res. 47, 1928-1939
   Abstract »    Full Text »    PDF »
Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity.
Y. Wang, D. Botolin, J. Xu, B. Christian, E. Mitchell, B. Jayaprakasam, M. Nair, J. M. Peters, J. Busik, L. K. Olson, et al. (2006)
J. Lipid Res. 47, 2028-2041
   Abstract »    Full Text »    PDF »
A role for skeletal muscle stearoyl-CoA desaturase 1 in control of thermogenesis.
D. Mainieri, S. Summermatter, J. Seydoux, J.-P. Montani, S. Rusconi, A. P. Russell, O. Boss, A. J. Buchala, and A. G. Dulloo (2006)
FASEB J 20, 1751-1753
   Abstract »    Full Text »    PDF »
Regulation of metabolic responses by adipocyte/ macrophage Fatty Acid-binding proteins in leptin-deficient mice..
H. Cao, K. Maeda, C. Z. Gorgun, H.-J. Kim, S.-Y. Park, G. I. Shulman, J. K. Kim, and G. S. Hotamisligil (2006)
Diabetes 55, 1915-1922
   Abstract »    Full Text »    PDF »
Leptin Suppresses Stearoyl-CoA Desaturase 1 by Mechanisms Independent of Insulin and Sterol Regulatory Element-Binding Protein-1c..
S. B. Biddinger, M. Miyazaki, J. Boucher, J. M. Ntambi, and C. R. Kahn (2006)
Diabetes 55, 2032-2041
   Abstract »    Full Text »    PDF »
The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis.
M. J. Wolfgang, T. Kurama, Y. Dai, A. Suwa, M. Asaumi, S.-i. Matsumoto, S. H. Cha, T. Shimokawa, and M. D. Lane (2006)
PNAS 103, 7282-7287
   Abstract »    Full Text »    PDF »
Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites.
J. S. Lee, S. K. Pinnamaneni, S. J. Eo, I. H. Cho, J. H. Pyo, C. K. Kim, A. J. Sinclair, M. A. Febbraio, and M. J. Watt (2006)
J Appl Physiol 100, 1467-1474
   Abstract »    Full Text »    PDF »
Diet-Genotype Interactions in the Development of the Obese, Insulin-Resistant Phenotype of C57BL/6J Mice Lacking Melanocortin-3 or -4 Receptors.
G. M. Sutton, J. L. Trevaskis, M. W. Hulver, R. P. McMillan, N. J. Markward, M. J. Babin, E. A. Meyer, and A. A. Butler (2006)
Endocrinology 147, 2183-2196
   Abstract »    Full Text »    PDF »
Liver X receptor agonist TO-901317 upregulates SCD1 expression in renal proximal straight tubule.
Y. Zhang, X. Zhang, L. Chen, J. Wu, D. Su, W. J. Lu, M.-T. Hwang, G. Yang, S. Li, M. Wei, et al. (2006)
Am J Physiol Renal Physiol 290, F1065-F1073
   Abstract »    Full Text »    PDF »
Identification of mouse palmitoyl-coenzyme A {Delta}9-desaturase.
M. Miyazaki, S. M. Bruggink, and J. M. Ntambi (2006)
J. Lipid Res. 47, 700-704
   Abstract »    Full Text »    PDF »
Leptin resistance following over-expression of protein tyrosine phosphatase 1B in liver.
N T Lam, S D Covey, J T Lewis, S Oosman, T Webber, E C Hsu, A T Cheung, and T J Kieffer (2006)
J. Mol. Endocrinol. 36, 163-174
   Abstract »    Full Text »    PDF »
The 103I Variant of the Melanocortin 4 Receptor Is Associated with Low Serum Triglyceride Levels.
G. Bronner, A. M. Sattler, A. Hinney, M. Soufi, F. Geller, H. Schafer, B. Maisch, J. Hebebrand, and J. R. Schaefer (2006)
J. Clin. Endocrinol. Metab. 91, 535-538
   Abstract »    Full Text »    PDF »
Membrane Topology of Mouse Stearoyl-CoA Desaturase 1.
W. C. Man, M. Miyazaki, K. Chu, and J. M. Ntambi (2006)
J. Biol. Chem. 281, 1251-1260
   Abstract »    Full Text »    PDF »
Expression and Regulation of the SCD2 Desaturase in the Rat Ovary.
C. Moreau, P. Froment, L. Tosca, V. Moreau, and J. Dupont (2006)
Biol Reprod 74, 75-87
   Abstract »    Full Text »    PDF »
Reduced Anorexigenic Efficacy of Leptin, But Not of the Melanocortin Receptor Agonist Melanotan-II, Predicts Diet-Induced Obesity in Rats.
G. van Dijk, K. de Vries, C. Nyakas, B. Buwalda, T. Adage, F. Kuipers, M. J. H. Kas, R. A. H. Adan, C. W. Wilkinson, T. E. Thiele, et al. (2005)
Endocrinology 146, 5247-5256
   Abstract »    Full Text »    PDF »
Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members.
A. C. Lake, Y. Sun, J.-L. Li, J. E. Kim, J. W. Johnson, D. Li, T. Revett, H. H. Shih, W. Liu, J. E. Paulsen, et al. (2005)
J. Lipid Res. 46, 2477-2487
   Abstract »    Full Text »    PDF »
Plasma palmitoleic acid content and obesity in children.
T. Okada, N. Furuhashi, Y. Kuromori, M. Miyashita, F. Iwata, and K. Harada (2005)
Am. J. Clinical Nutrition 82, 747-750
   Abstract »    Full Text »    PDF »
Intermittent Hypoxia Induces Hyperlipidemia in Lean Mice.
J. Li, L. N. Thorne, N. M. Punjabi, C.-K. Sun, A. R. Schwartz, P. L. Smith, R. L. Marino, A. Rodriguez, W. C. Hubbard, C. P. O'Donnell, et al. (2005)
Circ. Res. 97, 698-706
   Abstract »    Full Text »    PDF »
Leptin Improves Insulin Resistance and Hyperglycemia in a Mouse Model of Type 2 Diabetes.
Y. Toyoshima, O. Gavrilova, S. Yakar, W. Jou, S. Pack, Z. Asghar, M. B. Wheeler, and D. LeRoith (2005)
Endocrinology 146, 4024-4035
   Abstract »    Full Text »    PDF »
Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development.
M. Miyazaki, A. Dobrzyn, P. M. Elias, and J. M. Ntambi (2005)
PNAS 102, 12501-12506
   Abstract »    Full Text »    PDF »
A Toll-Like Receptor 2-Responsive Lipid Effector Pathway Protects Mammals against Skin Infections with Gram-Positive Bacteria.
P. Georgel, K. Crozat, X. Lauth, E. Makrantonaki, H. Seltmann, S. Sovath, K. Hoebe, X. Du, S. Rutschmann, Z. Jiang, et al. (2005)
Infect. Immun. 73, 4512-4521
   Abstract »    Full Text »    PDF »
Skeletal Muscle AMP-Activated Protein Kinase Phosphorylation Parallels Metabolic Phenotype in Leptin Transgenic Mice Under Dietary Modification.
T. Tanaka, S. Hidaka, H. Masuzaki, S. Yasue, Y. Minokoshi, K. Ebihara, H. Chusho, Y. Ogawa, T. Toyoda, K. Sato, et al. (2005)
Diabetes 54, 2365-2374
   Abstract »    Full Text »    PDF »
Stearoyl-CoA Desaturase 1 Deficiency Increases CTP:Choline Cytidylyltransferase Translocation into the Membrane and Enhances Phosphatidylcholine Synthesis in Liver.
A. Dobrzyn, P. Dobrzyn, M. Miyazaki, H. Sampath, K. Chu, and J. M. Ntambi (2005)
J. Biol. Chem. 280, 23356-23362
   Abstract »    Full Text »    PDF »
Changes in adipose tissue gene expression with energy-restricted diets in obese women.
I. Dahlman, K. Linder, E. Arvidsson Nordstrom, I. Andersson, J. Liden, C. Verdich, T. I. Sorensen, P. Arner, and Nugenob (2005)
Am. J. Clinical Nutrition 81, 1275-1285
   Abstract »    Full Text »    PDF »
Effects of Diet and Genetic Background on Sterol Regulatory Element-Binding Protein-1c, Stearoyl-CoA Desaturase 1, and the Development of the Metabolic Syndrome.
S. B. Biddinger, K. Almind, M. Miyazaki, E. Kokkotou, J. M. Ntambi, and C. R. Kahn (2005)
Diabetes 54, 1314-1323
   Abstract »    Full Text »    PDF »
Short-Term Overexpression of a Constitutively Active Form of AMP-Activated Protein Kinase in the Liver Leads to Mild Hypoglycemia and Fatty Liver.
M. Foretz, N. Ancellin, F. Andreelli, Y. Saintillan, P. Grondin, A. Kahn, B. Thorens, S. Vaulont, and B. Viollet (2005)
Diabetes 54, 1331-1339
   Abstract »    Full Text »    PDF »
Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression.
J. Halaschek-Wiener, J. S. Khattra, S. McKay, A. Pouzyrev, J. M. Stott, G. S. Yang, R. A. Holt, S. J.M. Jones, M. A. Marra, A. R. Brooks-Wilson, et al. (2005)
Genome Res. 15, 603-615
   Abstract »    Full Text »    PDF »
Fatty acid indices of stearoyl-CoA desaturase do not reflect actual stearoyl-CoA desaturase enzyme activities in adipose tissues of beef steers finished with corn-, flaxseed-, or sorghum-based diets.
S. L. Archibeque, D. K. Lunt, C. D. Gilbert, R. K. Tume, and S. B. Smith (2005)
J Anim Sci 83, 1153-1166
   Abstract »    Full Text »    PDF »
Moderate Caloric Restriction, But Not Physiological Hyperleptinemia Per Se, Enhances Mitochondrial Oxidative Capacity in Rat Liver and Skeletal Muscle--Tissue-Specific Impact on Tissue Triglyceride Content and AKT Activation.
R. Barazzoni, M. Zanetti, A. Bosutti, G. Biolo, L. Vitali-Serdoz, M. Stebel, and G. Guarnieri (2005)
Endocrinology 146, 2098-2106
   Abstract »    Full Text »    PDF »
Induction of Leptin Receptor Expression in the Liver by Leptin and Food Deprivation.
P. Cohen, G. Yang, X. Yu, A. A. Soukas, C. S. Wolfish, J. M. Friedman, and C. Li (2005)
J. Biol. Chem. 280, 10034-10039
   Abstract »    Full Text »    PDF »
Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing {beta}-oxidation in skeletal muscle.
A. Dobrzyn, P. Dobrzyn, S.-H. Lee, M. Miyazaki, P. Cohen, E. Asilmaz, D. G. Hardie, J. M. Friedman, and J. M. Ntambi (2005)
Am J Physiol Endocrinol Metab 288, E599-E607
   Abstract »    Full Text »    PDF »
Authors' Response: Haptoglobin and Body Mass Index.
C. Chiellini, F. Santini, A. Marsili, P. Vitti, A. Pinchera, and M. Maffei (2005)
J. Clin. Endocrinol. Metab. 90, 594-595
   Full Text »    PDF »
Engineering a pharmacologically superior form of leptin for the treatment of obesity.
K.-M. Lo, J. Zhang, Y. Sun, B. Morelli, Y. Lan, S. Lauder, B. Brunkhorst, G. Webster, S. Hallakou-Bozec, L. Doare, et al. (2005)
Protein Eng. Des. Sel. 18, 1-10
   Abstract »    Full Text »    PDF »
Transcript Profiling Suggests That Differential Metabolic Adaptation of Mice to a High Fat Diet Is Associated with Changes in Liver to Muscle Lipid Fluxes.
V. de Fourmestraux, H. Neubauer, C. Poussin, P. Farmer, L. Falquet, R. Burcelin, M. Delorenzi, and B. Thorens (2004)
J. Biol. Chem. 279, 50743-50753
   Abstract »    Full Text »    PDF »
Dietary Olive Oil and Menhaden Oil Mitigate Induction of Lipogenesis in Hyperinsulinemic Corpulent JCR:LA-cp Rats: Microarray Analysis of Lipid-Related Gene Expression.
X. Deng, M. B. Elam, H. G. Wilcox, L. M. Cagen, E. A. Park, R. Raghow, D. Patel, P. Kumar, A. Sheybani, and J. C. Russell (2004)
Endocrinology 145, 5847-5861
   Abstract »    Full Text »    PDF »
Effects of gender and GH secretory pattern on sterol regulatory element-binding protein-1c and its target genes in rat liver.
C. Ameen, D. Linden, B.-M. Larsson, A. Mode, A. Holmang, and J. Oscarsson (2004)
Am J Physiol Endocrinol Metab 287, E1039-E1048
   Abstract »    Full Text »    PDF »
Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism.
E. E. Zhang, E. Chapeau, K. Hagihara, and G.-S. Feng (2004)
PNAS 101, 16064-16069
   Abstract »    Full Text »    PDF »
Congenital Leptin Deficiency Due to Homozygosity for the {Delta}133G Mutation: Report of Another Case and Evaluation of Response to Four Years of Leptin Therapy.
W. T. Gibson, I. S. Farooqi, M. Moreau, A. M. DePaoli, E. Lawrence, S. O'Rahilly, and R. A. Trussell (2004)
J. Clin. Endocrinol. Metab. 89, 4821-4826
   Abstract »    Full Text »    PDF »
Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment.
S.-H. Lee, A. Dobrzyn, P. Dobrzyn, S. M. Rahman, M. Miyazaki, and J. M. Ntambi (2004)
J. Lipid Res. 45, 1674-1682
   Abstract »    Full Text »    PDF »
Leptin and the Control of Metabolism: Role for Stearoyl-CoA Desaturase-1 (SCD-1).
P. Cohen and J. M. Friedman (2004)
J. Nutr. 134, 2455S-2463S
   Abstract »    Full Text »    PDF »
Reduced Adiposity and Liver Steatosis by Stearoyl-CoA Desaturase Deficiency Are Independent of Peroxisome Proliferator-activated Receptor-{alpha}.
M. Miyazaki, A. Dobrzyn, H. Sampath, S.-H. Lee, W. C. Man, K. Chu, J. M. Peters, F. J. Gonzalez, and J. M. Ntambi (2004)
J. Biol. Chem. 279, 35017-35024
   Abstract »    Full Text »    PDF »
Stearoyl-CoA Desaturase 1 Gene Expression Is Necessary for Fructose-mediated Induction of Lipogenic Gene Expression by Sterol Regulatory Element-binding Protein-1c-dependent and -independent Mechanisms.
M. Miyazaki, A. Dobrzyn, W. C. Man, K. Chu, H. Sampath, H.-J. Kim, and J. M. Ntambi (2004)
J. Biol. Chem. 279, 25164-25171
   Abstract »    Full Text »    PDF »
Genetically Modified Animals in Endocrinology.
(2004)
Endocr. Rev. 25, 512-519
   Full Text »    PDF »
Fibroblast Growth Factor 19 Increases Metabolic Rate and Reverses Dietary and Leptin-Deficient Diabetes.
L. Fu, L. M. John, S. H. Adams, X. X. Yu, E. Tomlinson, M. Renz, P. M. Williams, R. Soriano, R. Corpuz, B. Moffat, et al. (2004)
Endocrinology 145, 2594-2603
   Abstract »    Full Text »    PDF »
Dwarfism and Impaired Gut Development in Insulin-Like Growth Factor II mRNA-Binding Protein 1-Deficient Mice.
T. V. O. Hansen, N. A. Hammer, J. Nielsen, M. Madsen, C. Dalbaeck, U. M. Wewer, J. Christiansen, and F. C. Nielsen (2004)
Mol. Cell. Biol. 24, 4448-4464
   Abstract »    Full Text »    PDF »
Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver.
P. Dobrzyn, A. Dobrzyn, M. Miyazaki, P. Cohen, E. Asilmaz, D. G. Hardie, J. M. Friedman, and J. M. Ntambi (2004)
PNAS 101, 6409-6414
   Abstract »    Full Text »    PDF »
Efficacy of Recombinant Methionyl Human Leptin Therapy for the Extreme Insulin Resistance of the Rabson-Mendenhall Syndrome.
E. Cochran, J. R. Young, N. Sebring, A. DePaoli, E. A. Oral, and P. Gorden (2004)
J. Clin. Endocrinol. Metab. 89, 1548-1554
   Abstract »    Full Text »    PDF »
Defective uptake of triglyceride-associated fatty acids in adipose tissue causes the SREBP-1c-mediated induction of lipogenesis.
E. M. Wagner, D. Kratky, G. Haemmerle, A. Hrzenjak, G. M. Kostner, E. Steyrer, and R. Zechner (2004)
J. Lipid Res. 45, 356-365
   Abstract »    Full Text »    PDF »
Update on Adipocyte Hormones: Regulation of Energy Balance and Carbohydrate/Lipid Metabolism.
P. J. Havel (2004)
Diabetes 53, S143-151
   Abstract »    Full Text »
Leptin Reverses the Inhibitory Effect of Caloric Restriction on Longitudinal Growth.
G. Gat-Yablonski, T. Ben-Ari, B. Shtaif, O. Potievsky, O. Moran, R. Eshet, G. Maor, Y. Segev, and M. Phillip (2004)
Endocrinology 145, 343-350
   Abstract »    Full Text »    PDF »
Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice.
M. W. Sleeman, K. Garcia, R. Liu, J. D. Murray, L. Malinova, M. Moncrieffe, G. D. Yancopoulos, and S. J. Wiegand (2003)
PNAS 100, 14297-14302
   Abstract »    Full Text »    PDF »
Coordinated Upregulation of Oxidative Pathways and Downregulation of Lipid Biosynthesis Underlie Obesity Resistance in Perilipin Knockout Mice: A Microarray Gene Expression Profile.
F. Castro-Chavez, V. K. Yechoor, P. K. Saha, J. Martinez-Botas, E. C. Wooten, S. Sharma, P. O'Connell, H. Taegtmeyer, and L. Chan (2003)
Diabetes 52, 2666-2674
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)