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Science 28 June 2002:
Vol. 296. no. 5577, pp. 2348 - 2349
DOI: 10.1126/science.1073846
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Perspectives

EVOLUTION:
Chaperones as Buffering Agents?

Thomas Mitchell-Olds and Charles A. Knight

It was predicted 60 years ago, that organisms must have a genetic buffering system that prevents numerous genetic variations from ever being expressed. In their Perspective, Mitchell-Olds and Knight discuss new work published elsewhere that implicates the molecular chaperone protein HSP90 in the genetic buffering of plant and animal cells.

The authors are at the Max Planck Institute for Chemical Ecology, Winzerlaer Strasse 10, Jena 07745, Germany. E-mail: tmo{at}ice.mpg.de

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