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Science 28 June 2002:
Vol. 296. no. 5577, pp. 2325 - 2326
DOI: 10.1126/science.296.5577.2325
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News Focus

VACCINES:
Monkey Puzzles

Jon Cohen

Almost 2 decades after HIV was identified as the cause of AIDS, researchers are still debating which immune responses are likely to provide the best protection against the virus. The answer is proving elusive in part because experiments with monkeys are coming up with puzzling, even contradictory, data. As a growing number of vaccines move through the pipeline toward clinical trials, these experiments are raising serious questions about most of the vaccine approaches now being pursued.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Potent, Persistent Induction and Modulation of Cellular Immune Responses in Rhesus Macaques Primed with Ad5hr-Simian Immunodeficiency Virus (SIV) env/rev, gag, and/or nef Vaccines and Boosted with SIV gp120.
L. J. Patterson, N. Malkevitch, J. Pinczewski, D. Venzon, Y. Lou, B. Peng, C. Munch, M. Leonard, E. Richardson, K. Aldrich, et al. (2003)
J. Virol. 77, 8607-8620
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Repression of the HIV-1 5' LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors.
L. Reynolds, C. Ullman, M. Moore, M. Isalan, M. J. West, P. Clapham, A. Klug, and Y. Choo (2003)
PNAS 100, 1615-1620
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