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Science 28 June 2002:
Vol. 296. no. 5577, p. 2293
DOI: 10.1126/science.296.5577.2293q
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Because of the high incidence of hypoxic disease processes such as heart attack and stroke, there is great need for a better understanding of the biological mechanisms that direct how an organism will respond to hypoxic conditions. Scott et al. (p. 2388; see the Perspective by Longo in SAGE) screened for hypoxia-resistant (Hyp) mutants in the worm Caenorhabditis elegans. Specific alleles of the DAF-2 insulin-like receptor confer a Hyp phenotype. Although DAF-2 mutant worms are known to be longer lived and resistant to various environmental stresses, the hypoxia pathway is distinct from the signaling pathways regulating life-span and stress resistance. In addition, the work shows that DAF-2 activity can be down-regulated prior to exposure to hypoxic conditions and provide a hypoxia-protective effect.




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