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Science 7 June 2002:
Vol. 296. no. 5574, pp. 1815 - 1817
DOI: 10.1126/science.296.5574.1815
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Perspectives

IMMUNOLOGY:
T Cell Activation in Six Dimensions

Ulrich H. von Andrian

What are T cells doing deep within the recesses of the lymph nodes they inhabit? In his Perspective, von Andrian discusses the findings of several studies that use two-photon and confocal microscopy to illuminate (literally) the private lives of T cells.

The author is at the Center for Blood Research, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA. E-mail: uva{at}cbr.med.harvard.edu

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Restricted Clonal Expression of IL-2 By Naive T Cells Reflects Differential Dynamic Interactions with Dendritic Cells.
V. Hurez, A. Saparov, A. Tousson, M. J. Fuller, T. Kubo, J. Oliver, B. T. Weaver, and C. T. Weaver (2003)
J. Exp. Med. 198, 123-132
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Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy.
M. J. Miller, S. H. Wei, M. D. Cahalan, and I. Parker (2003)
PNAS 100, 2604-2609
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