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Science 31 May 2002:
Vol. 296. no. 5573, pp. 1644 - 1646
DOI: 10.1126/science.1071549
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The Promise and Perils of Wnt Signaling Through beta -Catenin

Randall T. Moon,1* Bruce Bowerman,2 Michael Boutros,3 Norbert Perrimon3

Wnt pathways are involved in the control of gene expression, cell behavior, cell adhesion, and cell polarity. In addition, they often operate in combination with other signaling pathways. The Wnt/beta -catenin pathway is the best studied of the Wnt pathways and is highly conserved through evolution. In this pathway, Wnt signaling inhibits the degradation of beta -catenin, which can regulate transcription of a number of genes. Some of the genes regulated are those associated with cancer and other diseases (for example, colorectal cancer and melanomas). As a result, components of the Wnt/beta -catenin pathway are promising targets in the search for therapeutic agents. Information about Wnt pathways is available both in canonical terms and at the species level. In addition to the canonical Wnt/beta -catenin pathway, information is now available for Drosophila, Caenorhabditis elegans, and Xenopus. The STKE Connections Maps for these pathways provide an important tool in accessing this large body of complex information.

1 Howard Hughes Medical Institute, Department of Pharmacology, and Center for Developmental Biology, University of Washington School of Medicine, Seattle, WA 98195, USA.
2 Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA.
3 Howard Hughes Medical Institute and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
*   To whom correspondence should be addressed. E-mail: rtmoon{at}u.washington.edu

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