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Science 31 May 2002:
Vol. 296. no. 5573, pp. 1639 - 1640
DOI: 10.1126/science.1071551
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Viewpoint
Control of T Cell Function by Positive and Negative Regulators
Andrew L. Singer,
Gary A. Koretzky*
T cells are an essential element of the body's
immune system. Engagement of the T cell receptor is responsible for
initiating the signaling events that can activate, inactivate, or
eliminate T cells, depending on the magnitude and duration of the
signal. Control of T cell signaling occurs through both positive and
negative regulation, as well as through the actions of molecular
scaffolds that contribute to the formation of signaling complexes. The
T Cell Signal Transduction Pathway at the STKE Connections Maps highlights the molecular components that are responsible for T cell
activation. Understanding the mechanisms that regulate T cell
responsiveness will aid in the development of therapeutic agents to
treat infection, cancer, and autoimmune disease and immune deficiency.
The Abramson Family Cancer Research Institute, Department of
Laboratory Medicine and Pathology, University of Pennsylvania,
Philadelphia, PA 19104, USA.
*
To whom correspondence should be addressed. E-mail:
koretzky{at}mail.med.upenn.edu
Read the Full Text
The editors suggest the following Related Resources on Science sites:
In Science Signaling
- DATABASE OF CELL SIGNALING
T Cell Signal Transduction
- Andrew L. Singer, Jonathan Maltzman and Gary A. Koretzky
Sci. Signal. (Connections Map Pathway), http://stke.sciencemag.org/cgi/cm/stkecm;CMP_7019
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