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That HIV is able to escape the antibody response of the human immune system is well established. In a Perspective, McMichael and Klenerman explain new work (Moore et al.) providing evidence that HIV is able to mutate crucial epitopes, thus enabling the virus also to evade the host CTL immune response.
A. McMichael is at the Weatherall Institute of Molecular Medicine, Oxford OX3 9DS, UK. E-mail: andrew.mcmichael{at}clinical-medicine.oxford.ac.uk P. Klenerman is with the Medawar Centre for Pathogen Research, University of Oxford, Oxford OX1 IS5, UK.
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In Science Magazine
RESEARCH ARTICLES
Corey B. Moore, Mina John, Ian R. James, Frank T. Christiansen, Campbell S. Witt, and Simon A. Mallal (24 May 2002) Science296 (5572), 1439.
[DOI: 10.1126/science.1069660] |Abstract »|Full Text »|PDF »|Supplemental Data »
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