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Science 24 May 2002:
Vol. 296. no. 5572, pp. 1409 - 1410
DOI: 10.1126/science.1073339
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Perspectives

BIOCHEMISTRY:
The 22nd Amino Acid

John F. Atkins and Ray Gesteland

In their Perspective, Atkins and Gesteland discuss the discovery of the 22nd amino acid, pyrrolysine, in Archaea (Hao et al., Srinivasan et al.).

The authors are in the Department of Human Genetics, University of Utah, Salt Lake City, UT 84112-5330, USA. E-mail: john.atkins{at}genetics.utah.edu J.F.A. is also at the Science Foundation Ireland, Dublin 2, Ireland.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The three-dimensional structure of the Moorella thermoacetica selenocysteine insertion sequence RNA hairpin and its interaction with the elongation factor SelB.
A. V. Beribisky, T. J. Tavares, A. N. Amborski, M. Motamed, A. E. Johnson, T. L. Mark, and P. E. Johnson (2007)
RNA 13, 1948-1956
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A natural genetic code expansion cassette enables transmissible biosynthesis and genetic encoding of pyrrolysine.
D. G. Longstaff, R. C. Larue, J. E. Faust, A. Mahapatra, L. Zhang, K. B. Green-Church, and J. A. Krzycki (2007)
PNAS 104, 1021-1026
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The Residue Mass of L-Pyrrolysine in Three Distinct Methylamine Methyltransferases.
J. A. Soares, L. Zhang, R. L. Pitsch, N. M. Kleinholz, R. B. Jones, J. J. Wolff, J. Amster, K. B. Green-Church, and J. A. Krzycki (2005)
J. Biol. Chem. 280, 36962-36969
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Pyrrolysine and Selenocysteine Use Dissimilar Decoding Strategies.
Y. Zhang, P. V. Baranov, J. F. Atkins, and V. N. Gladyshev (2005)
J. Biol. Chem. 280, 20740-20751
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Atypical archaeal tRNA pyrrolysine transcript behaves towards EF-Tu as a typical elongator tRNA.
A. Theobald-Dietrich, M. Frugier, R. Giege, and J. Rudinger-Thirion (2004)
Nucleic Acids Res. 32, 1091-1096
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RECODE 2003.
P. V. Baranov, O. L. Gurvich, A. W. Hammer, R. F. Gesteland, and J. F. Atkins (2003)
Nucleic Acids Res. 31, 87-89
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Primer on Medical Genomics Part IV: Expression Proteomics.
A. Pardanani, E. D. Wieben, T. C. Spelsberg, and A. Tefferi (2002)
Mayo Clin. Proc. 77, 1185-1196
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