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Science 24 May 2002:
Vol. 296. no. 5572, pp. 1407 - 1408
DOI: 10.1126/science.1072445
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Perspectives

GENETICS:
Wild by Nature

Michael Wigler and Bud Mishra

How do networks of biological molecules, such as signal transduction pathways, operate, and are their behaviors predictable? In a Perspective, Wigler and Mishra explain a new study (Guet et al.) where the authors have designed a genetic combinatorial network and examined the predictability of its behavior.

M. Wigler and B. Mishra are at Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. E-mail: wigler{at}cshl.org B. Mishra is also at the Courant Institute of Mathematical Sciences, New York University, New York, NY 10012, USA.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)